Evidence map›Paper›PMID 34758081›Full record

ReviewDevelopment (Cambridge, England)2021

Microbial influences on gut development and gut-brain communication.

Lihua Ye, John F Rawls

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  6. Review
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  12. Who's talking to whom: microbiome-enteric nervous system interactions in early life.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  13. Factors Affecting Gut Microbiota of Puppies from Birth to Weaning.Animals : an open access journal from MDPI · 2023
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lihua YeDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-6790-9743
John F RawlsDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-5976-5206
Duke University · US

Funding

Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEIKH, SHEHZAD Z. · 2013 to 2023
$17.9M
Identifying genes required for digestive physiology and lipid metabolismR01DK093399 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, John F Rawls · 2013 to 2026
$7.6M
A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeuticsR24DK110492 · NIDDK · DUKE UNIVERSITY · PI RAWLS, JOHN F, SEED, PATRICK C. · 2016 to 2020
$7.2M
Immune Compromises Zebrafish for Cell TransplantationR24OD016761 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI LANGENAU, DAVID MICHAEL · 2013 to 2021
$5.2M
Microbial regulation of intestinal lipid metabolism and its physiological consequencesR01DK131742 · NIDDK · DUKE UNIVERSITY · PI RAWLS, JOHN F, YEN, CHI- LIANG ERIC · 2022 to 2025
$2.6M
Enteroendocrine cells sense gut bacteria and activate a gut-brain pathwayK01DK125527 · NIDDK · OHIO STATE UNIVERSITY · PI YE, LIHUA · 2021 to 2025
$729k
Dissecting the function of a microbial sensing gut-brain circuitR01DK142793 · NIDDK · OHIO STATE UNIVERSITY · PI Lihua Ye · 2026 to 2026
$649k
NIDDK NIH HHS K01 DK125527NIDDK NIH HHS P01 DK094779NIDDK NIH HHS R01 DK093399NIDDK NIH HHS R01 DK131742NIDDK NIH HHS R01 DK142793NIDDK NIH HHS R24 DK110492NIH HHS R24 OD016761
6 · The paper itself

Abstract

The developmental programs that build and sustain animal forms also encode the capacity to sense and adapt to the microbial world within which they evolved. This is abundantly apparent in the development of the digestive tract, which typically harbors the densest microbial communities of the body. Here, we review studies in human, mouse, zebrafish and Drosophila that are revealing how the microbiota impacts the development of the gut and its communication with the nervous system, highlighting important implications for human and animal health.

Indexed as

AnimalsBrain-Gut AxisCell LineageEnteric Nervous SystemGastrointestinal MicrobiomeGastrointestinal MotilityGastrointestinal TractHumansIntestinal MucosaNeuronsEnteroendocrine cellGastroenterologyGut-brain axisInteroceptionMicrobiomeStem cell

Identifiers

PMID34758081
PMCPMC8627602
OpenAlexW3214486541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.