Observational studyPLoS neglected tropical diseases2021
Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.
Observational study in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Public Health Response to Imported Hansen's Disease Cases and Contact Investigation Findings in the Chungcheong Region, 2024-2025.Public health weekly report · 2026Article
- Atypical Histoid Leprosy With Virchowian Features: A Report of a Histologically Deceptive Case.Cureus · 2025Article
- Preliminary evaluation of a neurological clinical pathway for the early detection of leprosy in low-endemic settings: A single-center exploratory study.Scientific reports · 2025Article
- Prevalence, patterns and determinants of peripheral neuropathy among leprosy patients in Northeast Ethiopia: A retrospective study.PLoS neglected tropical diseases · 2025Article
- Identifying promising peptide targets for leprosy serological tests: From prediction to ELISA.Journal, genetic engineering & biotechnology · 2025Article
- Potentially disabling factors of newly diagnosed leprosy patients in southwest China: a retrospective observational study.BMC public health · 2025Observational
- Misdiagnosis of Leprosy with Severe Reversal Reaction as Psoriatic Arthritis: A Case Report and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Article
- Socioeconomic determinants of the leprosy risk in Yunnan Province, China: a county-level spatiotemporal study.Frontiers in public health · 2025Article
- Progression of the leprosy reaction and nerve damage: A prospective cohort study in children with leprosy from the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
- The International Classification of Functioning, Disability and Health to map leprosy-related disability in rural and remote areas in Indonesia.PLoS neglected tropical diseases · 2024Article
- Burden of leprosy and associated risk factors for disabilities in Tanzania from 2017 to 2020.PloS one · 2024Article
- Prevalence and risk factors for disability in leprosy patients in Indonesia during the post-elimination era.Dermatology reports · 2023Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundLeprosy is potentially debilitating. The risk factors related to physical disabilities associated with leprosy disease in Yunnan, China was not clear. METHODOLOGY/PRINCIPAL
findingsWe studied 10644 newly detected leprosy patients from Yunnan, China, from 1990 to 2019. Factors associated with Grade 1 (G1D) and Grade 2 (G2D) physical disabilities or overall physical disabilities (combined G1D and G2D) associated with leprosy were analyzed using multinomial and ordinal logistic regression analyses. The following factors were associated with the development of physical disability in these patients with leprosy: delayed diagnosis [odds ratio (OR): 5.652, 4.399, and 2.275; 95% confidence intervals (CIs): 4.516-7.073, 3.714-5.212, and 2.063-2.509; for ≥ 10, 5-10 y, and 2-5 years, respectively], nerve damage (OR: 3.474 and 2.428; 95% CI: 2.843-4.244, and 1.959-3.008; for 2 and 1 damaged nerves, respectively), WHO classification of PB (OR: 1.759; 95% CI: 1.341-2.307), Ridley-Jopling classification (OR: 1.479, 1.438, 1.522 and 1.239; 95% CI: 1.052-2.079, 1.075-1.923, 1.261-1.838, and 1.072-1.431; for TT, BT, BB, and BL when compared with LL, respectively), advanced age (OR: 1.472 and 2.053; 95% CI: 1.106-1.960 and 1.498-2.814; for 15-59 and over 60 years old, respectively), zero skin lesions (OR: 1.916; 95% CI: 1.522-2.413), leprosy reaction (OR: 1.528; 95% CI: 1.195-1.952), rural occupation (OR: 1.364; 95% CI: 1.128-1.650), Han ethnicity (OR: 1.268; 95% CI: 1.159-1.386), and male sex (OR: 1.128; 95% CI: 1.024-1.243).
conclusionsDelayed diagnosis, nerve damage, no skin lesions, WHO and Ridley-Jopling classifications, leprosy reactions, advanced age, rural occupation, Han ethnicity, and male sex were associated with disability in leprosy patients. Identifying risk factors could help to prevent physical disability.
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