ArticleAmerican journal of veterinary research2021
Tuberculosis detection in nonhuman primates is enhanced by use of testing algorithms that include an interferon-γ release assay.
Article in American journal of veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Mtb-Specific Interferon-Gamma ELISpot Assays Have Greater Sensitivity for Detecting Mtb Infection Compared to Tuberculin Skin Test in a Cohort of Experimentally M. tuberculosis-Infected Macaques.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- The Role of Antibody Testing Using Commercially Available Reagents in Tuberculosis Surveillance Algorithms Being Developed for Nonhuman Primate Breeding Colonies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- A Systemic Approach to Chest Radiographic Assessment in Mycobacterium tuberculosis-Infected Cynomolgus Macaques (Macaca fascicularis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Characteristics of Tuberculosis Tests Performed during Postimport Quarantine of Nonhuman Primates, United States, 2021 to 2024.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Outbreak of Mycobacterium orygis in a Shipment of Cynomolgus Macaques Imported from Southeast Asia - United States, February-May 2023.MMWR. Morbidity and mortality weekly report · 2024Article
- The new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.PloS one · 2024Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo develop a testing algorithm that incorporates multiple assays to evaluate host cellular and humoral immunity and antigen detection concerning Mycobacterium tuberculosis complex (MTBC) infection in captive nonhuman primates. ANIMALS: Cohorts of captive-bred and wild-caught macaques from 5 different geographic regions. PROCEDURES: Macaques were tested for MTBC infection by use of a γ interferon tuberculosis (GIFT) assay, an interferon-γ release assay, and other assays. In the first 2 cohorts (n = 15 and 181), initial validation of the GIFT assay was performed by use of experimentally infected and unexposed control macaques. In the next 3 cohorts (n = 59, 42, and 11), results were obtained for opportunistically collected samples from macaques exposed during spontaneous outbreaks.
resultsSensitivity and specificity of the GIFT assay in the control cohorts were 100% and 97%, respectively, and were variable but enhanced by incorporating results from multiple assays in spontaneous outbreaks. CLINICAL RELEVANCE: The detection and management of MTBC infection in captive nonhuman primate populations is an ongoing challenge, especially with animal imports and transfers. Despite standardized practices of initial quarantine with regular intradermal tuberculin skin testing, spontaneous outbreaks continue to be reported. Since infection encompasses a range of disease manifestations over time, a testing algorithm that incorporates multiple assays, such as the GIFT assay, to evaluate host cellular and humoral immunity in addition to agent detection is needed. Testing a combination of samples from controlled studies and spontaneous outbreaks of MTBC infection in nonhuman primates would advance the development and validation of a functional algorithm that incorporates promising tools such as the GIFT assay.
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