Evidence map›Paper›PMID 34757864›Full record

ArticleCell transplantation

Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation.

Ruth E McDowell, Khawla F Ali, Saloni Lad, Vicente T San Martin, Rita Bottino, Matthew Walsh, Tyler Stevens, William Wilke, John P Kirwan, Betul Hatipoglu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ruth E McDowellDepartment of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Khawla F AliEndocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA.
Saloni LadCleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Vicente T San MartinEndocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA.
Rita BottinoInstitute for Cellular Therapeutics, Allegheny Health Network Research Institute, Pittsburgh, PA, USA.
Matthew WalshDigestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
Tyler StevensDigestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
William WilkeOrthopaedic & Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-1274-2701
John P KirwanDepartment of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-7321-9917
Betul HatipogluEndocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-5285-5858
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · USAllegheny Health Network · USPennington Biomedical Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inflammatory response is an obstacle to success in both allogeneic and autologous islet transplantation. In autologous islet transplantation (AIT), however, the recipient is also the donor, permitting pretreatment of donor/recipient for a controlled duration prior to transplantation. We sought to exploit this feature of (AIT) by pretreating donor/recipients with chronic pancreatitis undergoing total pancreatectomy and autologous islet transplantation (TPAIT) to test the hypothesis that peri-transplant treatment with the FDA-approved anti-inflammatory hydroxychloroquine (HCQ) improves graft function. In this randomized placebo-controlled pilot clinical study, patients (

Indexed as

Clinical Trials as TopicEnergy MetabolismEnzyme InhibitorsFemaleHumansHydroxychloroquineIslets of Langerhans TransplantationMalePilot ProjectsTransplantation, AutologousTreatment OutcomeEnzyme InhibitorsHydroxychloroquineautologous transplantationhydroxychloroquineinflammationislet transplantation

Identifiers

PMID34757864
PMCPMC8586172
OpenAlexW3214115724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.