Evidence map›Paper›PMID 34757848›Full record

ArticleJournal of virology2022

A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells.

Abhijit Basu, Srinivasa Penumutchu, Kien Nguyen, Uri Mbonye, Blanton S Tolbert, Jonathan Karn, Anton A Komar, Barsanjit Mazumder

Abstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Specialized Ribosomes in Health and Disease.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abhijit BasuCenter for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.
Srinivasa PenumutchuDepartment of Chemistry, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Kien NguyenDepartment of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Uri MbonyeDepartment of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Blanton S TolbertDepartment of Chemistry, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Jonathan KarnDepartment of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Anton A KomarCenter for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.
Barsanjit MazumderCenter for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.ORCID 0000-0003-3069-7833

Funding

Translational Silencing in Monocytes: Role of L13aR01HL079164 · NHLBI · CLEVELAND STATE UNIVERSITY · PI MAZUMDER, BARSANJIT · 2005 to 2019
$4.5M
STRUCTURAL BIOPHYSICS OF HIV ALTERNATIVE SPLICINGR01GM101979 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI TOLBERT, BLANTON SMITH · 2012 to 2016
$1.6M
eIF2A in translational controlR01GM128981 · NIGMS · CLEVELAND STATE UNIVERSITY · PI KOMAR, ANTON A. · 2020 to 2023
$1.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL79164HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM101979HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM128981NHLBI NIH HHS R01 HL079164NIGMS NIH HHS R01 GM101979NIGMS NIH HHS R01 GM128981Nord Family Foundation
6 · The paper itself

Abstract

The positive-sense, single-stranded RNA genome SARS-CoV-2 harbors functionally important

Indexed as

COVID-19Host Microbial InteractionsSARS-CoV-2A549 CellsHumansProtein BindingRNA, ViralVirus InternalizationRNA, Viralcell signalingribosomal loadingribosomal proteinsRNA virustranslational controlviral RNA elementvirus-host interactions

Identifiers

PMID34757848
PMCPMC8791291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.