Evidence map›Paper›PMID 34757841›Full record

ArticleJournal of virology2022

Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production.

Margarita V Rangel, Nicholas Catanzaro, Sara A Thannickal, Kelly A Crotty, Maria G Noval, Katherine E E Johnson, Elodie Ghedin, Helen M Lazear, Kenneth A Stapleford

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Margarita V RangelDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Nicholas CatanzaroDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Sara A ThannickalDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Kelly A CrottyDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Maria G NovalDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Katherine E E JohnsonCenter for Genomics & Systems Biology, Department of Biology, New York University, New York, New York, USA.
Elodie GhedinCenter for Genomics & Systems Biology, Department of Biology, New York University, New York, New York, USA.
Helen M LazearDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8649-4579
Kenneth A StaplefordDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-7796-2254
New York University · USUniversity of North Carolina at Chapel Hill · USNational Institutes of Health · US

Funding

INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
Genomic profiling of influenza infections to identify biomarkers of disease severityZIAAI001323 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GHEDIN, ELODIE · 2020 to 2025
$8.0M
The role of Interferon lambda signaling in flavivirus transmission and pathogenesis at the maternal-fetal interfaceR01AI139512 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI139512NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

Alphaviruses and flaviviruses have class II fusion glycoproteins that are essential for virion assembly and infectivity. Importantly, the tip of domain II is structurally conserved between the alphavirus and flavivirus fusion proteins, yet whether these structural similarities between virus families translate to functional similarities is unclear. Using

Indexed as

Virus ReplicationA549 CellsAlphavirusAmmonium ChlorideAnimalsCulicidaeFlavivirusHumansInterferon Type IMiceMice, Mutant StrainsMutationProtein DomainsViral Fusion ProteinsViral Nonstructural ProteinsVirionAmmonium ChlorideInterferon Type IViral Fusion ProteinsViral Nonstructural Proteinsalphavirusassemblyflavivirusfusion proteinglycoprotein

Identifiers

PMID34757841
PMCPMC8791257
OpenAlexW3214002090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.