Evidence map›Paper›PMID 34757799›Full record

ArticleScience advances2021

It happened again: Convergent evolution of acylglucose specialized metabolism in black nightshade and wild tomato.

Yann-Ru Lou, Thilani M Anthony, Paul D Fiesel, Rachel E Arking, Elizabeth M Christensen, A Daniel Jones, Robert L Last

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. New Acylglucoses fromPlants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Convergence and parallelism in the evolution of plant metabolism.Journal of integrative plant biology · 2026
    Review
  4. Article
  5. Article
  6. Metabolites · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Trading acyls and swapping sugars: metabolic innovations inbioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yann-Ru LouDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-4716-4323
Thilani M AnthonyDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Paul D FieselDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-2038-5417
Rachel E ArkingDepartment of Neuroscience, East Lansing, MI 48824, USA.ORCID 0000-0002-6645-7068
Elizabeth M ChristensenDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-9036-3603
A Daniel JonesDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-7408-6690
Robert L LastDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-6974-9587

Funding

Plant Biotechnology for Health and SustainabilityT32GM110523 · NIGMS · MICHIGAN STATE UNIVERSITY · PI LAST, ROBERT LOUIS · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM110523
6 · The paper itself

Abstract

Plants synthesize myriad phylogenetically restricted specialized (aka “secondary”) metabolites with diverse structures. Metabolism of acylated sugar esters in epidermal glandular secreting trichomes across the Solanaceae (nightshade) family is ideal for investigating the mechanisms of evolutionary metabolic diversification. We developed methods to structurally analyze acylhexose mixtures by 2D NMR, which led to the insight that the Old World species black nightshade (

Identifiers

PMID34757799
PMCPMC8580325

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.