ReviewHypertension (Dallas, Tex. : 1979)2021
SPRINT Revisited: Updated Results and Implications.
Abstract readReview
In one paragraph
Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systolic blood pressure targets below 120 mm Hg are associated with reduced mortality: A meta-analysis.Journal of internal medicine · 2025Pooled it
- Intensive Blood Pressure Treatment Goals: Evidence for Cardiovascular Protection From Observational Studies and Clinical Trials.American journal of hypertension · 2022Pooled it
- Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.JAMA network open · 2023Trial
- Evaluation of guideline adherence to hypertension-mediated organ damage screening in Korean patients with hypertension: results from the Korean Registry of Target Organ Damage in Hypertension (KorHR).Clinical hypertension · 2026Article
- The Systolic Blood Pressure Intervention Trial: 10 Years Later.Journal of the American College of Cardiology · 2025Article
- Review
- Effect of Systolic Blood Pressure Measurement Error on the Cost-Effectiveness of Intensive Blood Pressure Targets.Annals of internal medicine · 2025Article
- Healthy ageing in older adults with cardiovascular disease.European heart journal · 2025Review
- Obesity Biomarkers: Exploring Factors, Ramification, Machine Learning, and AI-Unveiling Insights in Health Research.MedComm · 2025Review
- Clinical Trials in Hypertension: A Mathematical Endorsement for Diagnosis and Treatment.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Sex-based comparison of the blood pressure, haemodynamic and cardiac autonomic adaptations following isometric exercise training in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2025Article
- Incidence and Associated Risk Factors of Hypertension among Apparently Healthy Adult Filipinos in the LIFECARE Philippine Cohort Study.Acta medica Philippina · 2025Article
- The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial.EClinicalMedicine · 2024Article
- The Polypill: A New Alternative in the Prevention and Treatment of Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Standing Blood Pressure and Risk of Falls, Syncope, Coronary Heart Disease, and Mortality.American journal of hypertension · 2023Article
- Editors' Commentary on the 2023 ESH Management of Arterial Hypertension Guidelines.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Hypertensive Heart Failure.Journal of clinical medicine · 2023Review
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Jackson T WrightFrom the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH.ORCID 0000-0003-2557-7239
Paul K WheltonDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana (P.K.W.).ORCID 0000-0002-2225-383X
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.).
Joni K SnyderClinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
David M ReboussinDepartment of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.
William C CushmanDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.).ORCID 0000-0001-7162-2972
Jeff D WilliamsonSection of Gerontology and Geriatric Medicine (J.D.W.), Wake Forest School of Medicine, Winston-Salem, NC.
Nicholas M PajewskiDepartment of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0002-4447-6196
Alfred K CheungRenal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.).
Cora E LewisDivision of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C., S.B.).ORCID 0000-0002-2301-5796
Suzanne OparilDepartment of Epidemiology (C.E.L.), University of Alabama at Birmingham.ORCID 0000-0002-7505-2599
Michael V RoccoSection on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0003-0544-6071
Srinivasan BeddhuRenal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.).
Lawrence J FineClinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
Jeffrey A CutlerClinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
Walter T AmbrosiusDepartment of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.
Mahboob RahmanFrom the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH.ORCID 0000-0001-9025-7413
Carolyn H StillFrances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH.
Zhengyi ChenDepartment of Medicine (S.O.), University of Alabama at Birmingham.ORCID 0000-0002-2745-4454
Curtis TatsuokaDepartment of Medicine (S.O.), University of Alabama at Birmingham.
SPRINT Research Group
Funding
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MMichigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MStanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MTufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4MUniversity of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MNCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR002548NCATS NIH HHS UL1 TR003142NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNHLBI NIH HHS R21 HL145494NIA NIH HHS P30 AG049638NIDDK NIH HHS R01 DK118219NIGMS NIH HHS P20 GM109036NIGMS NIH HHS P30 GM103337
Abstract
The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this article is to respond to key questions that have been raised.
Indexed as
Randomized Controlled Trials as TopicAntihypertensive AgentsBlood PressureHumansHypertensionTreatment OutcomeAntihypertensive Agentsblood pressurecardiovascular diseasecontrolled clinical trialheart failurehypertensionmyocardial infarction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.