Evidence map›Paper›PMID 34757576›Full record

ArticleJournal of nephrology2022

Novel 3D capsule device to restrict kidney volume expansion on polycystic kidney progression: feasibility study in a rat model.

Kyongtae T Bae, Kanako Kumamoto, Aya Yoshimura, Masanori Kugita, Shigeo Horie, Tamio Yamaguchi, Junu T Bae, Shizuko Nagao

Abstract read
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In one paragraph

Article in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Kyongtae T BaeDepartment of Radiology, University of Pittsburgh School of Medicine, 300 Halket St. Suite C-316, Pittsburgh, PA, 15213, USA. kyongtaebae@gmail.com.
Kanako Kumamoto *Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, Aichi, 470-1192, Japan.
Aya Yoshimura *Education and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, Aichi, 470-1192, Japan.
Masanori KugitaEducation and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, Aichi, 470-1192, Japan.
Shigeo HorieDepartment of Urology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Tamio YamaguchiDepartment of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan.
Junu T BaeOhio State University College of Medicine, Columbus, OH, USA.
Shizuko NagaoEducation and Research Facility of Animal Models for Human Diseases, Center for Research Promotion and Support, Fujita Health University, 1-98 Dengakugakubo Kutsukake, Toyoke, Aichi, 470-1192, Japan. shizun@fujita-hu.ac.jp.
Fujita Health University Hospital · JPJuntendo University · JPSuzuka University of Medical Science · JPThe Ohio State University · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied to cystic kidneys to restrict tubular lumen dilatation and cyst expansion.

methodsKidney capsule devices were designed from computed tomography images of wild-type and Cy/+ rats. Capsule devices were surgically implanted on kidneys in six surgical sessions over a period of 14 months in 7 wild-type rats of 6.5-8 weeks (3 sham operations, 2 right, 2 left) and 6 Cy/+ rats of 6.5 weeks (2 sham, 3 left, 1 bilateral). After surgery, the rats were followed for 5.4-12.4 weeks' growth and sacrificed to retrieve the kidneys. During the follow-up, serum creatinine was measured and retrieved kidneys were weighed. Histological analysis including cystic area measurement and immunohistochemistry was performed.

resultsMorphometric capsule devices were configured and developed by an image processing technique and produced using a 3D printer. Encapsulated Cy/+ kidneys (n = 5; mean weight 3.64 g) were consistently smaller in size (by 21-36%; p < 0.001) than unencapsulated Cy/+ kidneys (n = 7; mean weight 5.52 g). Encapsulated Cy/+ kidneys (mean %cyst area: 29.4%) showed smaller histological cystic area (by 28-58%; p < 0.001) than unencapsulated Cy/+ kidneys (mean %cyst area 48.6%). Cell proliferation and macrophages were also markedly reduced in encapsulated Cy/+ kidneys, compared to unencapsulated Cy/+ kidneys.

conclusionsWe report a pilot feasibility study for the application of a novel morphometric 3D capsule device to the Cy/+ rat model showing restricted kidney volume expansion on polycystic kidney disease progression.

Indexed as

CystsPolycystic Kidney DiseasesAnimalsCell ProliferationDisease Models, AnimalFeasibility StudiesHumansKidneyRats3D printingImage-processingInterventionPolycystic kidney diseaseRodent experiment

Identifiers

PMID34757576
OpenAlexW3213983613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.