Evidence map›Paper›PMID 34757565›Full record

ArticleInternational ophthalmology2022

Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands.

Reydson Alcides de Lima-Souza, Natália de Magalhães Rodrigues, João Figueira Scarini, Mário Fernandez Sobral Silva, Alfio José Tincani, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Abstract read
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In one paragraph

Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Reydson Alcides de Lima-Souza *Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5045-6960
Natália de Magalhães Rodrigues *Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6469-5065
João Figueira ScariniDepartment of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9015-6831
Mário Fernandez Sobral SilvaDepartment of Surgery, Head and Neck Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7279-2655
Alfio José TincaniDepartment of Surgery, Head and Neck Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6193-2686
Erika Said Abu EgalDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9429-6743
Albina AltemaniDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9944-9734
Fernanda Viviane MarianoDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. fmariano@unicamp.br.ORCID http://orcid.org/0000-0003-3694-5025
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

fundação de amparo à pesquisa do estado de são paulo 15/07304-0fundação de amparo à pesquisa do estado de são paulo 19/06809-2fundação de amparo à pesquisa do estado de são paulo 19/10788-0
6 · The paper itself

Abstract

purposeTo evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG).

methodsFour samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases.

resultsWas observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples.

conclusionsIn conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.

Indexed as

AdenocarcinomaAdenoma, PleomorphicCarcinomaLacrimal ApparatusHumansPerilipin-2Perilipin-2Carcinoma ex pleomorphic adenomaGlycogenesisLacrimal glandsLipogenesisMetabolismPleomorphic adenoma

Identifiers

PMID34757565
OpenAlexW3214134233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.