Evidence map›Paper›PMID 34757564›Full record

Trial reportBrain imaging and behavior2021

Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial.

Benjamin Sinclair, Chris Steward, Vijay Venkatraman, Rowa Aljondi, Kay L Cox, Kathryn A Ellis, David Ames, Colin L Masters, Pramit M Phal, Matthew J Sharman and 5 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Benjamin SinclairDepartment of Radiology, University of Melbourne, Melbourne, Australia. benjamin.james.sinclair@gmail.com.ORCID http://orcid.org/0000-0002-0850-3644
Chris StewardDepartment of Radiology, University of Melbourne, Melbourne, Australia.
Vijay VenkatramanDepartment of Radiology, University of Melbourne, Melbourne, Australia.
Rowa AljondiDepartment of Radiology, University of Melbourne, Melbourne, Australia.
Kay L CoxMedical School, University of Western Australia, Perth, Australia.
Kathryn A EllisAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
David AmesAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Colin L MastersThe Florey Institute, University of Melbourne, Melbourne, Australia.
Pramit M PhalDepartment of Radiology, University of Melbourne, Melbourne, Australia.
Matthew J SharmanSchool of Health Science, University of Tasmania, Hobart, Australia.
Elizabeth V CyartoBolton Clarke Research Institute, Brisbane, Australia.
Michelle M Y LaiAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Cassandra SzoekeUniversity of Melbourne, Melbourne, Australia.
Nicola T LautenschlagerUniversity of Melbourne, Melbourne, Australia.
Patricia M DesmondDepartment of Radiology, University of Melbourne, Melbourne, Australia.
The University of Melbourne · AUThe Royal Melbourne Hospital · AUThe University of Queensland · AUThe University of Western Australia · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.

Indexed as

Cognitive DysfunctionDementiaAgedAtrophyBrainCognitionExerciseHumansMagnetic Resonance ImagingBrain volumeDementiaMild cognitive impairmentPhysical activityVoxel-based Morphometry

Identifiers

PMID34757564
OpenAlexW3212110116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.