SynthesisJournal of anesthesia2022
Effects of individualized positive end-expiratory pressure combined with recruitment maneuver on intraoperative ventilation during abdominal surgery: a systematic review and network meta-analysis of randomized controlled trials.
Synthesis in Journal of anesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06123039 (Use of Heart-lung Interaction Parameters to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP During Invasive Mechanical Ventilation in the Operating Room), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Heart-lung Interaction Parameters to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP During Invasive Mechanical Ventilation in the Operating Room
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Pooled it
- The effect of alveolar recruitment maneuver on intraoperative hemodynamics: A randomized controlled trial.Medicine · 2026Trial
- [Effects of a lung recruitment maneuver combined with individualized positive end-expiratory pressure on postoperative pulmonary complications and perioperative hemodynamics in hypertensive patients undergoing pulmonary resection].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Trial
- Effects of individualized PEEP titration on intraoperative cardiac output in thoracoscopic lung surgery: a prospective randomized trial.Scientific reports · 2026Trial
- Ultrasound guided individualized PEEP reduces postoperative atelectasis in elderly patients undergoing laparoscopic radical rectal cancer surgery.Scientific reports · 2025Trial
- Respiratory variation in carotid artery blood flow peak velocity combined with tidal volume challenge in predicting fluid responsiveness of lung-protective ventilation patients: a feasibility study.Journal of clinical monitoring and computing · 2026Article
- "Tailored" vs. "one-size-fits-all": current knowledge of individualized PEEP and constant PEEP strategy during the perioperative period.European journal of medical research · 2025Review
- Effect of positive end-expiratory pressure on risk of microaspiration and ventilator-associated pneumonia in mechanically ventilated ICU patients: a prospective study.Journal of cardiothoracic surgery · 2025Article
- Article
- Effect of different positive end-expiratory pressure levels in patients undergoing laparoscopic cholecystectomy under general anesthesia.Pakistan journal of medical sciences · 2025Article
- Methods for determining optimal positive end-expiratory pressure in patients undergoing invasive mechanical ventilation: a scoping review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Effects of lung protection ventilation strategies on postoperative pulmonary complications after noncardiac surgery: a network meta-analysis of randomized controlled trials.BMC anesthesiology · 2024Article
- The Effect of Increased Intra-Abdominal Pressure on Hemodynamics in Laparoscopic Cholecystectomy-The Experience of a Single Centre.Journal of personalized medicine · 2024Article
- The Effect of Recruitment Maneuver on Static Lung Compliance in Patients Undergoing General Anesthesia for Laparoscopic Cholecystectomy: A Single-Centre Prospective Clinical Intervention Study.Medicina (Kaunas, Lithuania) · 2024Article
- Interpreting and assessing confidence in network meta-analysis results: an introduction for clinicians.Journal of anesthesia · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low tidal volume ventilation strategy may lead to atelectasis without proper positive end-expiratory pressure (PEEP) and recruitment maneuver (RM) settings. RM followed by individualized PEEP was a new method to optimize the intraoperative pulmonary function. We conducted a systematic review and network meta-analysis of randomized clinical trials to compare the effects of individualized PEEP + RM on intraoperative pulmonary function and hemodynamic with other PEEP and RM settings. The primary outcomes were intraoperative oxygenation index and dynamic compliance, while the secondary outcomes were intraoperative heart rate and mean arterial pressure. In total, we identified 15 clinical trials containing 36 randomized groups with 3634 participants. Ventilation strategies were divided into eight groups by four PEEP (L: low, M: moderate, H: high, and I: individualized) and two RM (yes or no) settings. The main results showed that IPEEP + RM group was superior to all other groups regarding to both oxygenation index and dynamic compliance. LPEEP group was inferior to LPEEP + RM, MPEEP, MPEEP + RM, and IPEEP + RM in terms of oxygenation index and LPEEP + RM, MPEEP, MPEEP + RM, HPEEP + RM, IPEEP, and IPEEP + RM in terms of dynamic compliance. All comparisons were similar for secondary outcomes. Our analysis suggested that individualized PEEP and RM may be the optimal low tidal volume ventilation strategy at present, while low PEEP without RM is not suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.