Evidence map›Paper›PMID 34757232›Full record

ArticleActa biomaterialia2022

Synergistic interventional photothermal therapy and immunotherapy using an iron oxide nanoplatform for the treatment of pancreatic cancer.

Meng Wang, Yong Li, Miao Wang, Kaili Liu, Ashley R Hoover, Min Li, Rheal A Towner, Priyabrata Mukherjee, Feifan Zhou, Junle Qu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

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  13. New Strategies for Macrophage Re-Education in Cancer: An Update.International journal of molecular sciences · 2024
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  20. Magnetically Actuated Biodegradable Nanorobots for Active Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Meng WangKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Yong LiInterventional Therapy Department, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Miao WangSchool of Biomedical Engineering, Hainan University, Haikou 570228, China.
Kaili LiuStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USA.
Ashley R HooverStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USA.
Min LiDepartment of Medicine, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Rheal A TownerAdvanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Priyabrata MukherjeeDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Feifan ZhouSchool of Biomedical Engineering, Hainan University, Haikou 570228, China. Electronic address: zhouff@hainanu.edu.cn.
Junle QuKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address: jlqu@szu.edu.cn.
Wei R ChenStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USA. Electronic address: Wei-R-hen@ou.edu.
Shenzhen University · CNUniversity of Oklahoma · USUniversity of Oklahoma Health Sciences Center · USHainan University · CNOklahoma Medical Research Foundation · USTianjin Medical University Cancer Institute and Hospital · CN

Funding

Mechanistic study on synergistic photo-immunological effects of laser immunotherapy for metastatic cancersR01CA205348 · NCI · UNIVERSITY OF OKLAHOMA · PI CHEN, WEI R. · 2017 to 2021
$1.5M
Pre-Clinical 7T MRI for OklahomaS10OD023508 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI TOWNER, RHEAL A · 2017 to 2017
$600k
NCI NIH HHS R01 CA205348NIH HHS S10 OD023508
6 · The paper itself

Abstract

Pancreatic cancer (PC) is the most lethal malignancy due to its high metastatic ability and poor drug permeability. Here, a synergized interventional photothermal-immunotherapy strategy was developed with imaging guidance and temperature monitoring by magnetic resonance imaging (MRI) technique, for the local treatment of metastatic PC. A tumor microenvironment (TME)-responsive nanoplatform was fabricated via coating of DSPE-PEG and indocyanine green (ICG) onto imiquimod (IMQ) loaded amorphous iron oxide nanoparticles (IONs). This unique nanoplatform, IMQ@IONs/ICG, served as a contrast agent for MRI, a drug delivery vehicle for IMQ and ICG, and a catalyst for TME modulation. The biodegradable IMQ@IONs/ICG was also non-toxic, and improved the penetration of the loaded drugs in PC to maximize thermal ablation of the tumor and minimize damage to the surrounding healthy tissue. For the treatment of aggressive, metastatic Panc02-H7 pancreatic tumors in mice, ION-assisted MRI was employed to guide the administration of interventional photothermal therapy (IPTT) and monitor the temperature distribution in target tumor and surrounding tissue during treatment. The local IPTT treatment induced in situ immunogenic cell death (ICD), and, in combination with released IMQ, triggered a strong antitumor immunity, leading to decreased metastases and increased CD8

Indexed as

NanoparticlesPancreatic NeoplasmsAnimalsCell Line, TumorFerric CompoundsImmunotherapyIndocyanine GreenMicePhototherapyPhotothermal TherapyTumor MicroenvironmentFerric Compoundsferric oxideIndocyanine GreenAmorphous iron oxide nanoparticleImmunotherapyInterventional photothermal therapyMagnetic resonance temperature imagingPancreatic cancer

Identifiers

PMID34757232
PMCPMC10960566
OpenAlexW3208038826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.