Evidence map›Paper›PMID 34757008›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022

COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report.

Wayne F Leung, Samuel Chorlton, John Tyson, Ghada N Al-Rawahi, Agatha N Jassem, Natalie Prystajecky, Shazia Masud, Gregory D Deans, Michael G Chapman, Yazdan Mirzanejad and 2 more

Abstract readCase Reports
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
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  10. Stuck in pandemic uncertainty: a review of the persistent effects of COVID-19 infection in immune-deficient people.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2024
    Review
  11. Viruses · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Rapid dynamic changes of FL.2 variant: A case report of COVID-19 breakthrough infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  17. Antiviral and Monoclonal Antibody Combination Therapy in Haematological Patients in the Omicron Era.Mediterranean journal of hematology and infectious diseases · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wayne F LeungFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Samuel ChorltonFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
John TysonBritish Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
Ghada N Al-RawahiDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Agatha N JassemDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
Natalie PrystajeckyDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
Shazia MasudDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Gregory D DeansDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Michael G ChapmanDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Yazdan MirzanejadDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Melanie C M MurrayDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Patrick H P WongDivision of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: patricke@mail.ubc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

Indexed as

COVID-19SARS-CoV-2AdultFemaleHumansImmunocompromised HostMutationVirus SheddingYoung AdultCase reportImmunocompromisedMutationSARS-CoV-2SequencingViral culture

Identifiers

PMID34757008
PMCPMC8553657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.