Evidence map›Paper›PMID 34756987›Full record

ArticleNeuroscience2022

Assessing Local and Branch-specific Activity in Dendrites.

Jason J Moore, Vincent Robert, Shannon K Rashid, Jayeeta Basu

Open access · greenAbstract read
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
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  7. Article
  8. Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Article
  11. How far neuroscience is from understanding brains.Frontiers in systems neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jason J MooreNeuroscience Institute, New York University Langone Health, New York, NY 10016, USA.
Vincent RobertNeuroscience Institute, New York University Langone Health, New York, NY 10016, USA.
Shannon K RashidNeuroscience Institute, New York University Langone Health, New York, NY 10016, USA.
Jayeeta BasuNeuroscience Institute, New York University Langone Health, New York, NY 10016, USA; Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: jayeeta.basu@nyulangone.org.
NYU Langone Health · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2M
Reexamining the Role of Dendrites in Neuronal FunctionRM1NS132981 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Jayeeta Basu, RAFAEL YUSTE · 2023 to 2026
$10.3M
Linking Plasticity of Hippocampal Representation across the Single Neuron and Circuit LevelsR01NS109994 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BASU, JAYEETA, CLOPATH, CLAUDIA · 2018 to 2022
$2.4M
Synaptic and Circuit Interactions to Shape Multisensory Processing - Administrative SupplementR01NS109362 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BASU, JAYEETA · 2018 to 2023
$1.9M
NIGMS NIH HHS T32 GM007308NINDS NIH HHS R01 NS109362NINDS NIH HHS R01 NS109994NINDS NIH HHS RM1 NS132981
6 · The paper itself

Abstract

Dendrites are elaborate neural processes which integrate inputs from various sources in space and time. While decades of work have suggested an independent role for dendrites in driving nonlinear computations for the cell, only recently have technological advances enabled us to capture the variety of activity in dendrites and their coupling dynamics with the soma. Under certain circumstances, activity generated in a given dendritic branch remains isolated, such that the soma or even sister dendrites are not privy to these localized signals. Such branch-specific activity could radically increase the capacity and flexibility of coding for the cell as a whole. Here, we discuss these forms of localized and branch-specific activity, their functional relevance in plasticity and behavior, and their supporting biophysical and circuit-level mechanisms. We conclude by showcasing electrical and optical approaches in hippocampal area CA3, using original experimental data to discuss experimental and analytical methodology and key considerations to take when investigating the functional relevance of independent dendritic activity.

Indexed as

DendritesPyramidal CellsAction PotentialsHippocampusNeuronsblind dendritic patch clamp electrophysiologybranch specific activitydendritic spikesfeature tuningGABAergic circuitrytwo-photon imaging

Identifiers

PMID34756987
PMCPMC9125998
OpenAlexW3208238094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.