Evidence map›Paper›PMID 34756176›Full record

ReviewThe Lancet. Public health2022

Primary stroke prevention worldwide: translating evidence into action.

Mayowa O Owolabi, Amanda G Thrift, Ajay Mahal, Marie Ishida, Sheila Martins, Walter D Johnson, Jeyaraj Pandian, Foad Abd-Allah, Joseph Yaria, Hoang T Phan and 10 more

Erratum issued 3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 284 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 15 pooled it
49.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06341881 nacompletednot on this mapstarted 2024, after this paper: background citation

Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan

TypeinterventionalSponsorKhyber Medical University PeshawarRan2024 to 2025Enrolled60ConditionsStroke, Stroke, Ischemic, Stroke HemorrhagicArmsTransitional Care Training Program
NCT06817512 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Health Effects of Vitamin K2 Supplementation on Skeletal Muscle and Neurological Function After Ischemic Stroke

TypeinterventionalSponsorHarbin Medical UniversityRan2025 to 2028Enrolled190ConditionsIschemic StrokeArmsVitamin K2, Placebo
NCT06842095 narecruitingnot on this mapstarted 2025, after this paper: background citation

Investigating the Effects of Beta Transcranial Stimulation to Advance Stroke Rehabilitation

TypeinterventionalSponsorUniversity of OxfordRan2025 to 2027Enrolled60ConditionsStroke, Upper Limb FunctionArmsTranscranial Alternating Current Stimulation (beta-tACS), Transcranial Alternating Current Stimulation (sham)
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 15 syntheses or guidelines pooled it, 471 citations in OpenAlex.

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  4. Combined exercise training to improve gait in older stroke patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  5. Measurement properties of Chinese-version assessment tools of health-related quality of life in patients with stroke: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 6 countries.

Mayowa O OwolabiCenter for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: mayowaowolabi@yahoo.com.
Amanda G ThriftStroke and Ageing Research, Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Ajay MahalNossal Institute for Global Health, University of Melbourne, Melbourne, VIC, Australia.
Marie IshidaNossal Institute for Global Health, University of Melbourne, Melbourne, VIC, Australia.
Sheila MartinsDepartment of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Neurology, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil; Department of Neurology, Hospital Moinhos de Vento, Porto Alegre, Brazil; Brazilian Stroke Network, São Paulo, Brazil.
Walter D JohnsonSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.
Jeyaraj PandianSchool of Public Health, Christian Medical College, Ludhiana, Punjab, India.
Foad Abd-AllahDepartment of Neurology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Joseph YariaDepartment of Neurology, University College Hospital, Ibadan, Nigeria.
Hoang T PhanDepartment of Neurology, Monash University, Melbourne, VIC, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Greg RothInstitute for Health Metrics Evaluation, University of Washington, Seattle, WA, USA.
Seana L GallMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Richard BeareMonash Health, and Peninsula Clinical School, Monash University, Melbourne, VIC, Australia; Developmental Imaging Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Thanh G PhanDepartment of Neurology, Monash University, Melbourne, VIC, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Robert MikulikInternational Clinical Research Center, Neurology Department, St Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Rufus O AkinyemiInstitute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Bo NorrvingDepartment of Clinical Sciences, and Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.
Michael BraininDepartment of Neuroscience and Preventive Medicine, Danube University Krems, Krems an der Donau, Austria.
Valery L FeiginInstitute for Health Metrics Evaluation, University of Washington, Seattle, WA, USA; National Institute for Stroke and Applied Neurosciences, School of Clinical Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand; Scientific and Educational Department, Research Centre of Neurology, Moscow, Russia. Electronic address: valery.feigin@aut.ac.nz.
Stroke Experts Collaboration Group
University of Melbourne · AUCairo University · EGChristian Medical College & Hospital · INLoma Linda University · USUniversität für Weiterbildung Krems · ATUniversity College Hospital, Ibadan · NGUniversity of Ibadan · NGUniversity of Tasmania · AUUniversity of Washington · US

Funding

H3Africa Administrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in AfricaU24HG009780 · NHGRI · UNIVERSITY OF CAPE TOWN · PI SKELTON, MICHELLE · 2017 to 2022
$4.8M
Stroke Investigative Research & Educational Network (SIREN)U54HG007479 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2013 to 2017
$4.2M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES)R01NS115944 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2020 to 2025
$2.2M
Systematic Investigation of Blacks with Stroke - Genomics (SIBS-Genomics) StudyR01NS107900 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2018 to 2021
$1.8M
Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS)D43TW012030 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OVBIAGELE, BRUCE · 2021 to 2025
$1.2M
Sub-Saharan Africa Conference on Stroke (SSACS) ConferenceR13NS115395 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI OVBIAGELE, BRUCE · 2020 to 2020
$50k
FIC NIH HHS D43 TW012030NHGRI NIH HHS U24 HG009780NHGRI NIH HHS U54 HG007479NINDS NIH HHS R01 NS107900NINDS NIH HHS R01 NS114045NINDS NIH HHS R01 NS115944NINDS NIH HHS R13 NS115395
6 · The paper itself

Abstract

Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.

Indexed as

Costs and Cost AnalysisDeveloping CountriesGlobal HealthHealth PolicyHumansStroke

Identifiers

PMID34756176
PMCPMC8727355
OpenAlexW3208183713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.