ArticleeLife2021
Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change.
Erratum issuedAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 99 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.Molecular psychiatry · 2023Pooled it
- Structural and social determinants of health shape the impact of neurodegeneration and cerebrovascular pathology on cognitive functioning in black adults.Social science & medicine (1982) · 2026Article
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- Aging beyond diagnosis: the MRI brain age gap across disorders.GeroScience · 2026Review
- From whole-body to organ-specific biological age clocks.Nature aging · 2026Review
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Longitudinal Trajectories of Cortical Folding in Schizophrenia Spectrum Disorders: A 13-Year Follow-Up Study.Schizophrenia bulletin · 2026Article
- Brain Age in Adult Patients With Early-Treated Phenylketonuria.Journal of inherited metabolic disease · 2026Article
- CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals.Annals of clinical and translational neurology · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Brain age gradients as intermediate phenotypes linking plasma p-tau217 to cognition in community-dwelling older adults.NPJ dementia · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Prediction of brain age using structural magnetic resonance imaging: a comparison of clinical utility of publicly available software packages.EBioMedicine · 2026Article
- BrainAgeMS: protocol for a prospective comparative study of brain aging in healthy adults and people with multiple sclerosis.Frontiers in neurology · 2026Observational
- Shared genetic architecture of brain age gap across 30 cohorts worldwide.medRxiv : the preprint server for health sciences · 2025Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
31 authors.
Didac Vidal-PineiroCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0001-9997-9156
Yunpeng WangCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Stine K KrogsrudCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Inge K AmlienCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
William F C BaaréDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.
David Bartres-FazDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0001-6020-4118
Lars BertramCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Andreas M BrandmaierMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.ORCID https://orcid.org/0000-0001-8765-6982
Christian A DrevonDepartment of Nutrition, Inst Basic Med Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo, Norway.ORCID https://orcid.org/0000-0002-7216-2784
Sandra DüzelCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Klaus EbmeierDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-5190-7038
Richard N HensonMRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Carme JunquéDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Rogier Andrew KievitMRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-0700-4568
Simone KühnLise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany.ORCID https://orcid.org/0000-0001-6823-7969
Esten LeonardsenCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Ulman LindenbergerMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.ORCID https://orcid.org/0000-0001-8428-6453
Kathrine S MadsenDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.
Fredrik MagnussenCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0003-2574-1705
Athanasia Monika MowinckelCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-5756-0223
Lars NybergUmeå Centre for Functional Brain Imaging, Department of Integrative Medical Biology, Physiology Section and Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-3367-1746
James M RoeCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Barbara SeguraDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Stephen M SmithCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.ORCID https://orcid.org/0000-0001-8166-069X
Øystein SørensenCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Sana SuriWellcome Centre for Integrative Neuroimaging (WIN FMRIB), University of Oxford, Oxford, United Kingdom.
Rene WesterhausenSection for Cognitive Neuroscience and Neuropsychology, Department of Psychology, University of Oslo, Oslo, Norway.
Andrew ZaleskyDepartment of Biomedical Engineering, Faculty of Engineering and IT, The University of Melbourne, Melbourne, Australia.
Enikő ZsoldosWellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-0478-6165
Kristine Beate WalhovdCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Anders FjellCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Funding
Biotechnology and Biological Sciences Research Council BB/H008217/1British Heart FoundationCancer Research UKDepartment of HealthEuropean Research Council 677804Medical Research Council G1001354Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00005/8Medical Research Council MR/K013351/1Medical Research Council SUAG/046 G101400Wellcome TrustWellcome Trust 203139/Z/16/Z
Abstract
PubMed holds no abstract for this paper.
Indexed as
GenotypeAgingBirth WeightBrainCross-Sectional StudiesGenome-Wide Association StudyHumansLongitudinal StudiesMagnetic Resonance ImagingAgingBrain age deltabrain age gapbrain declinehumanneuroimagingneuroscienceT1w
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.