Evidence map›Paper›PMID 34755646›Full record

ArticleClinica chimica acta; international journal of clinical chemistry2021

SARS-CoV-2 neutralizing antibodies after one or two doses of Comirnaty (BNT162b2, BioNTech/Pfizer): Kinetics and comparison with chemiluminescent assays.

Andrea Padoan, Chiara Cosma, Francesco Bonfante, Foscarina Della Rocca, Francesco Barbaro, Claudia Santarossa, Luigi Dall'Olmo, Matteo Pagliari, Alessio Bortolami, Annamaria Cattelan and 3 more

Open access · greenAbstract read
In one paragraph

Article in Clinica chimica acta; international journal of clinical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  14. Not all SARS-CoV-2 IgG and neutralizing antibody assays are created equal.Clinica chimica acta; international journal of clinical chemistry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Andrea PadoanDepartment of Medicine-DIMED, University of Padua, Italy; Department of Laboratory Medicine, University-Hospital of Padua, Italy.
Chiara CosmaDepartment of Laboratory Medicine, University-Hospital of Padua, Italy.
Francesco BonfanteLaboratory of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Foscarina Della RoccaEmergency Department, Padua University Hospital, Padua, Italy.
Francesco BarbaroInfective and Tropical Disease Unit, Padua University Hospital, Padua, Italy.
Claudia SantarossaEmergency Department, Padua University Hospital, Padua, Italy.
Luigi Dall'OlmoDepartment of Surgical Oncological and Gastroenterological Sciences - DISCOG, University of Padua, Italy; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Matteo PagliariLaboratory of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Alessio BortolamiLaboratory of Experimental Animal Models, Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Annamaria CattelanInfective and Tropical Disease Unit, Padua University Hospital, Padua, Italy.
Vito CianciEmergency Department, Padua University Hospital, Padua, Italy.
Daniela BassoDepartment of Medicine-DIMED, University of Padua, Italy; Department of Laboratory Medicine, University-Hospital of Padua, Italy.
Mario PlebaniDepartment of Medicine-DIMED, University of Padua, Italy; Department of Laboratory Medicine, University-Hospital of Padua, Italy. Electronic address: mario.plebani@unipd.it.
University of Padua · ITIstituto Zooprofilattico Sperimentale delle Venezie · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies evaluating neutralizing antibody (NAb) after BNT162b2 vaccine are scarce. We therefore compared NAb using the plaque reduction neutralization test (PRNT) in vaccinated subjects, with those from five chemiluminescent (CLIA) assays, two targeting ACE and S-RBD interaction.

methodsSera from 174 completely Comirnaty/BNT162b2 vaccinated healthcare workers (HCW) were evaluated at t

resultsNeither PRNT

conclusionsComirnaty/BNT162b2 elicits strong NAb production, especially 28 days after first inoculum. Differences in correlation between Nab titers and circulating antibodies measured by 5 immunoassays have been found, being stronger the correlation for Maglumi Nab.

Indexed as

COVID-19SARS-CoV-2AdultAgedAntibodies, NeutralizingBNT162 VaccineHumansKineticsLuminescent MeasurementsMiddle AgedYoung AdultAntibodies, NeutralizingBNT162 VaccineAntibodyBNT162b2ComirnatyCOVID-19ImmunoassaysImmunological responseSARS-CoV-2 vaccineSerology

Identifiers

PMID34755646
PMCPMC8553360
OpenAlexW3210974312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.