Evidence map›Paper›PMID 34755642›Full record

ArticleJournal of molecular and cellular cardiology2022

Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes.

Disha Varma, Jonathas F Q Almeida, Jaime DeSantiago, Lothar A Blatter, Kathrin Banach

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  5. Review
  6. Article
  7. The role of P21-activated kinase (Pak1) in sinus node function.Journal of molecular and cellular cardiology · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Disha VarmaDept. of Internal Medicine/Cardiology, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA. Electronic address: Disha_Varma@rush.edu.
Jonathas F Q AlmeidaDept. of Internal Medicine/Cardiology, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA. Electronic address: Jonathas_F_Almeida@rush.edu.
Jaime DeSantiagoDept. of Physiology & Biophysics, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA. Electronic address: Jaime_DeSantiago@rush.edu.
Lothar A BlatterDept. of Physiology & Biophysics, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA. Electronic address: Lothar_Blatter@rush.edu.
Kathrin BanachDept. of Internal Medicine/Cardiology, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA. Electronic address: Kathrin_Banach@rush.edu.

Funding

Limiting Pathological Calcium Induced Calcium Release in HeartR01HL057832 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, GILLESPIE, DIRK · 1997 to 2024
$9.0M
Atrial Excitation-Contraction Coupling, Calcium Signaling and Electro-Mechanical AlternansR01HL164453 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BANACH, KATHRIN, KANAPORIS, GIEDRIUS · 2022 to 2025
$2.8M
IP3 receptor, NOX2 and calcium signaling domains in atrial physiology and pathophysiologyR01HL155762 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BANACH, KATHRIN · 2022 to 2025
$2.7M
The Role of p21-activated Kinase (Pak1) in Atrial FibrillationR01HL128330 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BANACH, KATHRIN · 2016 to 2019
$1.7M
Pathophysiological Regulation of Atrial Alternans and Atrial FibrillationR01HL132871 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BANACH, KATHRIN, BLATTER, LOTHAR A · 2017 to 2020
$1.6M
Pathophysiological Regulation of Atrial Myocyte Excitation-Contraction Coupling and Calcium SignalingR01HL134781 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BLATTER, LOTHAR A · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL057832NHLBI NIH HHS R01 HL128330NHLBI NIH HHS R01 HL132871NHLBI NIH HHS R01 HL134781NHLBI NIH HHS R01 HL155762NHLBI NIH HHS R01 HL164453
6 · The paper itself

Abstract

The inositol 1,4,5-trisphosphate receptor (InsP

Indexed as

Atrial FibrillationOxygenAnimalsCalciumHumansInositolInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMiceMyocytes, CardiacReactive Oxygen SpeciesCalciumInositolInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsOxygenReactive Oxygen SpeciesAngiotensin IIAtrial excitation contraction couplingInositol 1,4,5-trisphosphate receptor induced Ca(2+) releaseNADPH oxidase 2Signaling domain

Identifiers

PMID34755642
PMCPMC8826595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.