Evidence map›Paper›PMID 34755600›Full record

ArticleeLife2021

Amelia E Hinman, Charul Jani, Stephanie C Pringle, Wei R Zhang, Neharika Jain, Amanda J Martinot, Amy K Barczak

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. A specialized CD107aiScience · 2026
    Article
  2. Article
  3. Review
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Vps18 contributes to phagosome membrane integrity inbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amelia E HinmanThe Ragon Institute, Massachusetts General Hospital, Cambridge, United States.
Charul JaniThe Ragon Institute, Massachusetts General Hospital, Cambridge, United States.
Stephanie C PringleThe Ragon Institute, Massachusetts General Hospital, Cambridge, United States.
Wei R ZhangThe Ragon Institute, Massachusetts General Hospital, Cambridge, United States.
Neharika JainDepartment of Infectious Diseases and Global Health, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, United States.
Amanda J MartinotDepartment of Infectious Diseases and Global Health, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, United States.
Amy K BarczakThe Ragon Institute, Massachusetts General Hospital, Cambridge, United States.ORCID 0000-0003-3806-2381
Ragon Institute of MGH, MIT and Harvard · USTufts University · USHarvard University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
High-Throughput TB Vaccine Antigen DiscoveryK08AI135098 · NIAID · TUFTS UNIVERSITY BOSTON · PI MARTINOT, AMANDA · 2018 to 2022
$931k
NIAID NIH HHS K08 AI135098NIAID NIH HHS P30 AI060354
6 · The paper itself

Abstract

For many intracellular pathogens, the phagosome is the site of events and interactions that shape infection outcome. Phagosomal membrane damage, in particular, is proposed to benefit invading pathogens. To define the innate immune consequences of this damage, we profiled macrophage transcriptional responses to wild-type

Indexed as

AnimalsMacrophagesMiceMycobacterium tuberculosisToll-Like Receptor 2Virulence FactorsTlr2 protein, mouseToll-Like Receptor 2Virulence Factorsimmunologyinfectious diseaseinflammationmicrobiologyMycobacterium tuberculosisTLR2tuberculosis

Identifiers

PMID34755600
PMCPMC8610422
OpenAlexW3212622084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.