Evidence map›Paper›PMID 34755599›Full record

ArticleeLife2021

Circuits for integrating learned and innate valences in the insect brain.

Claire Eschbach, Akira Fushiki, Michael Winding, Bruno Afonso, Ingrid V Andrade, Benjamin T Cocanougher, Katharina Eichler, Ruben Gepner, Guangwei Si, Javier Valdes-Aleman and 7 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. The larvalScience advances · 2026
    Article
  4. Article
  5. Article
  6. Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  7. The larvalbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Claire Eschbach *HHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-8092-3440
Akira Fushiki *HHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-7987-6405
Michael WindingHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0003-1965-3266
Bruno AfonsoHHMI Janelia Research Campus, Richmond, United Kingdom.
Ingrid V AndradeHHMI Janelia Research Campus, Richmond, United Kingdom.
Benjamin T CocanougherHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0003-0648-554X
Katharina EichlerHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-7833-8621
Ruben GepnerDepartment of Physics, New York University, New York, United States.
Guangwei SiDepartment of Physics, Harvard University, Cambridge, United States.
Javier Valdes-AlemanHHMI Janelia Research Campus, Richmond, United Kingdom.
Richard D FetterHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-1558-100X
Marc GershowDepartment of Physics, New York University, New York, United States.ORCID 0000-0001-7528-6101
Gregory Sxe JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0002-0587-9355
Aravinthan Dt SamuelDepartment of Physics, Harvard University, Cambridge, United States.ORCID 0000-0002-1672-8720
James W TrumanHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-9209-5435
Albert CardonaHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0003-4941-6536
Marta ZlaticHHMI Janelia Research Campus, Richmond, United Kingdom.ORCID 0000-0002-3149-2250
Janelia Research Campus · USMRC Laboratory of Molecular Biology · GBHarvard University · USUniversity of California, Los Angeles · USNeurosciences Institute · USNew York University · US

Funding

Howard Hughes Medical InstituteMedical Research Council MC_UP_1201/20Medical Research Council MC_UP_1201/21Wellcome Trust 205038/A/16/ZWellcome Trust 205038/Z/16/ZWellcome Trust 205050/B/16/ZWellcome Trust 205050/C/16/ZWellcome Trust 205050/Z/16/ZWellcome Trust RG86459
6 · The paper itself

Abstract

Animal behavior is shaped both by evolution and by individual experience. Parallel brain pathways encode innate and learned valences of cues, but the way in which they are integrated during action-selection is not well understood. We used electron microscopy to comprehensively map with synaptic resolution all neurons downstream of all mushroom body (MB) output neurons (encoding learned valences) and characterized their patterns of interaction with lateral horn (LH) neurons (encoding innate valences) in

Indexed as

AnimalsBrainConnectomeDrosophila melanogasterLarvaLearningMushroom BodiesNeuronsaction selectionconnectomeD. melanogasterlearnt behaviorneurosciencevalence

Identifiers

PMID34755599
PMCPMC8616581
OpenAlexW3212123783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.