SynthesisJournal of the American Heart Association2021
Atrial High-Rate Episode Duration Thresholds and Thromboembolic Risk: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07447297 (Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk and protective factors for stroke and transient ischaemic attack in patients with atrial fibrillation: an umbrella review of meta-analyses.Heart (British Cardiac Society) · 2026Pooled it
- Incremental predictive value of device and echocardiographic parameters for atrial high-rate episodes: a prospective cohort study.BMC cardiovascular disorders · 2026Article
- Device-detected Atrial Fibrillation: How Much is Too Much?Arrhythmia & electrophysiology review · 2026Review
- Left Ventricular Mass Index and Relative Wall Thickness Predict Atrial High-Rate Episodes in Patients With Pacemaker Implantation.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Clinical relevance and management of atrial high-rate episodes: a narrative review.Archivos de cardiologia de Mexico · 2025Review
- Non-Anticoagulation Strategies Aimed at Primary Stroke Prevention in Nascent Atrial Fibrillation.Biomedicines · 2025Review
- Safety and Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases: A Scoping Review.Journal of the American Heart Association · 2024Article
- Atrial Imaging and Cardiac Rhythm in Cryptogenic Embolic Stroke: The ARIES Study.Journal of the American Heart Association · 2024Observational
- Atrial High-Rate Episodes and Subclinical Atrial Fibrillation: State of the Art and Clinical Questions with Complex Solutions.Reviews in cardiovascular medicine · 2024Review
- Atrial High-Rate Episodes in Elderly Patients: The Anticoagulation Therapy Dilemma.Journal of clinical medicine · 2024Review
- Management of ischaemic stroke survivors in primary care setting: the road to holistic care.Internal and emergency medicine · 2024Review
- The incidence of atrial fibrillation, new oral anticoagulation, stroke, and significant bleeds in patients receiving a new dual-chamber pacemaker.International journal of cardiology. Heart & vasculature · 2023Article
- Pharmacological therapy in adult congenital heart disease with coronary artery disease and atrial fibrillation.International journal of cardiology. Congenital heart disease · 2023Review
- Stroke in Atrial Fibrillation and Other Atrial Dysrhythmias.Current cardiology reports · 2023Review
- Role of atrial high-rate episodes in stratifying thromboembolic risk: a multiple cut-off diagnostic meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Sinus rhythm restoration and improved outcomes in patients with acute ischemic stroke and in-hospital paroxysmal atrial fibrillation.European stroke journal · 2022Article
- When to set anticoagulant therapy in asymptomatic AF? looking for a cut-off duration.European heart journal supplements : journal of the European Society of Cardiology · 2022Article
- How should I treat patients with subclinical atrial fibrillation and atrial high-rate episodes? Current evidence and clinical importance.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Available evidence supports an association between atrial high-rate episode (AHRE) burden and thromboembolic risk, but the necessary extent and duration of AHREs to increase the thromboembolic risk remain to be defined. The aim of this systematic review and meta-analysis was to identify the thromboembolic risk associated with various AHRE thresholds. Methods and Results We searched PubMed and Scopus until January 9, 2020, for literature reporting AHRE duration and thromboembolic risk in patients with implantable electronic devices. The outcome assessed was stroke or systemic embolism. Risk estimates were reported as hazard ratio (HR) or relative risk alongside 95% CIs. We used the Paule-Mandel estimator, and heterogeneity was calculated with I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.