Evidence map›Paper›PMID 34755532›Full record

ArticleJournal of the American Heart Association2021

Cardiovascular Morbidity and Mortality in Adult Patients With Repaired Aortic Coarctation.

Timion A Meijs, Savine C S Minderhoud, Steven A Muller, Robbert J de Winter, Barbara J M Mulder, Joost P van Melle, Elke S Hoendermis, Arie P J van Dijk, Nicolaas P A Zuithoff, Gregor J Krings and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Primary aortic coarctation repair in adolescents and adults.JTCVS structural and endovascular · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Biological Age in Congenital Heart Disease-Exploring the Ticking Clock.Journal of cardiovascular development and disease · 2023
    Review
  15. Comparison of aortic stiffness and hypertension in repaired coarctation patients with a bicuspid versus a tricuspid aortic valve.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Timion A MeijsDepartment of Cardiology University Medical Center Utrecht Utrecht The Netherlands.ORCID 0000-0002-7320-996X
Savine C S MinderhoudDepartment of Cardiology Erasmus Medical Center Rotterdam The Netherlands.
Steven A MullerDepartment of Cardiology University Medical Center Utrecht Utrecht The Netherlands.ORCID 0000-0002-2674-8709
Robbert J de WinterDepartment of Cardiology Amsterdam UMC, Location Academic Medical Center Amsterdam The Netherlands.
Barbara J M MulderDepartment of Cardiology Amsterdam UMC, Location Academic Medical Center Amsterdam The Netherlands.
Joost P van MelleDepartment of Cardiology University Medical Center Groningen Groningen The Netherlands.
Elke S HoendermisDepartment of Cardiology University Medical Center Groningen Groningen The Netherlands.
Arie P J van DijkDepartment of Cardiology Radboud University Medical Center Nijmegen The Netherlands.
Nicolaas P A ZuithoffDepartment of Epidemiology and Biostatistics Julius Center for Health Sciences and Primary Care Utrecht The Netherlands.
Gregor J KringsDepartment of Pediatric Cardiology Wilhelmina Children's Hospital Utrecht The Netherlands.ORCID 0000-0002-2453-3181
Pieter A DoevendansDepartment of Cardiology University Medical Center Utrecht Utrecht The Netherlands.ORCID 0000-0002-6257-7169
Maarten WitsenburgDepartment of Cardiology Erasmus Medical Center Rotterdam The Netherlands.ORCID 0000-0001-6099-7111
Jolien W Roos-HesselinkDepartment of Cardiology Erasmus Medical Center Rotterdam The Netherlands.ORCID 0000-0002-6770-3830
Annemien E van den BoschDepartment of Cardiology Erasmus Medical Center Rotterdam The Netherlands.
Berto J BoumaDepartment of Cardiology Amsterdam UMC, Location Academic Medical Center Amsterdam The Netherlands.ORCID 0000-0002-1433-9692
Michiel VoskuilDepartment of Cardiology University Medical Center Utrecht Utrecht The Netherlands.
Erasmus MC · NLUniversity Medical Center Utrecht · NLAmsterdam UMC Location University of Amsterdam · NLUniversity Medical Center Groningen · NLRadboud University Nijmegen · NLWilhelmina Children's Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The long-term burden of cardiovascular disease after repair of coarctation of the aorta (CoA) has not been elucidated. We aimed to determine the incidence of and risk factors for cardiovascular events in adult patients with repaired CoA. Additionally, mortality rates were compared between adults with repaired CoA and the general population. Methods and Results Using the Dutch Congenital Corvitia (CONCOR) registry, patients aged ≥16 years with previous surgical or transcatheter CoA repair from 5 tertiary referral centers were included. Cardiovascular events were recorded, comprising coronary artery disease, stroke/transient ischemic attack, aortic complications, arrhythmias, heart failure hospitalizations, endocarditis, and cardiovascular death. In total, 920 patients (median age, 24 years [range 16-74 years]) were included. After a mean follow-up of 9.3±5.1 years, 191 patients (21%) experienced at least 1 cardiovascular event. A total of 270 cardiovascular events occurred, of which aortic complications and arrhythmias were most frequent. Older age at initial CoA repair (hazard ratio [HR], 1.017; 95% CI, 1.000-1.033 [

Indexed as

Aortic CoarctationAdolescentAdultAgedAortaArrhythmias, CardiacDisease ProgressionHumansMiddle AgedProspective StudiesRetrospective StudiesYoung Adultadult congenital heart diseaseaortic coarctationcardiovascular eventssurvival

Identifiers

PMID34755532
PMCPMC8751912
OpenAlexW3214228122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.