Evidence map›Paper›PMID 34755500›Full record

ReviewZoological research2021

Understanding autism spectrum disorders with animal models: applications, insights, and perspectives.

Zhu Li, Yuan-Xiang Zhu, Li-Jun Gu, Ying Cheng

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Zoological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  7. Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhu LiInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan 650500, China.
Yuan-Xiang ZhuInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan 650500, China.
Li-Jun GuInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan 650500, China.
Ying ChengInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan 650500, China. E-mail:ycheng@ynu.edu.cn.
Yunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its highly heterogeneous nature. To better understand the pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, and idiopathic animal models. In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models.

Indexed as

Autism Spectrum DisorderDisease Models, AnimalAnimalsHumansAnimal modelsAutism spectrum disordersEnvironmentGeneticsNeurodevelopment

Identifiers

PMID34755500
PMCPMC8645879
OpenAlexW3211227797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.