Evidence map›Paper›PMID 34755487›Full record

ArticlePhysiological reports2021

Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice.

Timothy M Moore, Anthony Terrazas, Alexander R Strumwasser, Amanda J Lin, Xiaopeng Zhu, Akshay T S Anand, Christina Q Nguyen, Linsey Stiles, Frode Norheim, Jennifer M Lang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Timothy M MooreDivision of Cardiology, Department of Medicine, University of California, Los Angeles, California, USA.
Anthony TerrazasDivision of Cardiology, Department of Medicine, University of California, Los Angeles, California, USA.
Alexander R StrumwasserDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.
Amanda J LinDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.
Xiaopeng ZhuDivision of Pediatric Endocrinology, Department of Pediatrics UCLA Children's Discovery and Innovation Institute, Department of Medicine, University of California, Los Angeles, California, USA.
Akshay T S AnandDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.
Christina Q NguyenDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.
Linsey StilesDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.
Frode NorheimDepartment of Human Genetics, University of California, Los Angeles, California, USA.ORCID 0000-0002-5319-5679
Jennifer M LangDepartment of Human Genetics, University of California, Los Angeles, California, USA.
Simon T HuiDivision of Cardiology, Department of Medicine, University of California, Los Angeles, California, USA.
Lorraine P TurcotteDepartment of Biological Sciences, Dana & David Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.
Zhenqi ZhouDivision of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, California, USA.ORCID 0000-0001-6560-9704
University of California, Los Angeles · USUniversity of Southern California · US

Funding

UCLA Medical Genetics Training ProgramT32GM008243 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Julian Martinez-Agosto, STANLEY F. NELSON · 1987 to 2026
$6.8M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Muscle Cell Biology, Pathophysiology, and TherapeuticsT32AR065972 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rachelle Hope Crosbie, THOMAS A. RANDO · 2016 to 2026
$3.9M
Neuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9M
Role of dynamin-related protein 1 in the regulation of metabolism and skeletal muscle massR01DK125354 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, ZHENQI · 2021 to 2025
$2.5M
NEPHROLOGY SCIENTIST TRAINING GRANTT32DK007789 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURTZ, IRA · 2000 to 2017
$1.5M
Mitochondrial DNA Health and Metabolic HomeostasisF31DK108657 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MOORE, TIMOTHY MICHAEL · 2016 to 2018
$126k
NIAMS NIH HHS T32 AR065972NICHD NIH HHS T32 HD007228NIDDK NIH HHS F31 DK108657NIDDK NIH HHS R01 DK117850NIDDK NIH HHS R01 DK125354NIDDK NIH HHS T32 DK007789NIGMS NIH HHS T32 GM008243
6 · The paper itself

Abstract

The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well understood. We sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of the metabolic syndrome and its associated diseases. We also analyzed the impact of physical activity under metabolic syndrome progression upon the gut microbiome composition. Utilizing whole-body low-density lipoprotein receptor (LDLR) knockout mice on a "Western Diet," we show that long-term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Exercise increased mitochondrial abundance in skeletal muscle but did not reduce liver fibrosis, aortic lesion area, or plasma lipids. Lastly, we observed several changes in gut bacteria and their novel associations with metabolic parameters of clinical importance. Altogether, our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome composition.

Indexed as

Gastrointestinal MicrobiomeAdiposityAnimalsGlucoseLiverMaleMetabolic SyndromeMiceMice, Inbred C57BLMitochondria, LiverPhysical Conditioning, AnimalReceptors, LDLRunningGlucoseReceptors, LDLexerciseLDLRmetabolic syndromemicrobiomeobesity

Identifiers

PMID34755487
PMCPMC8578881
OpenAlexW3212945816

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.