Evidence map›Paper›PMID 34755347›Full record

ArticleJournal of medical virology2022

Remitting neuropsychiatric symptoms in COVID-19 patients: Viral cause or drug effect?

David A Forero-Peña, Matthew M Hernandez, Iriana Paola Mozo Herrera, Iván Bolívar Collado Espinal, Joselyn Páez Paz, Carlos Ferro, David M Flora-Noda, Andrea L Maricuto, Viledy L Velásquez, Natasha A Camejo-Avila and 6 more

Abstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

David A Forero-PeñaDepartment of Infectious Diseases, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0002-8065-8464
Matthew M HernandezDepartment of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-6217-7264
Iriana Paola Mozo HerreraPsychiatry Department, University Military Hospital ″Dr. Carlos Arvelo ″, Caracas, Venezuela.ORCID 0000-0002-4682-0325
Iván Bolívar Collado EspinalPsychiatry Department, University Military Hospital ″Dr. Carlos Arvelo ″, Caracas, Venezuela.ORCID 0000-0001-9429-9784
Joselyn Páez PazPsychiatry Department, University Military Hospital ″Dr. Carlos Arvelo ″, Caracas, Venezuela.ORCID 0000-0002-8243-7358
Carlos FerroPsychiatry Department, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0003-3872-0954
David M Flora-NodaDepartment of Infectious Diseases, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0001-8153-4458
Andrea L MaricutoDepartment of Infectious Diseases, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0002-3557-0877
Viledy L VelásquezDepartment of Infectious Diseases, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0003-0261-3559
Natasha A Camejo-AvilaDepartment of Infectious Diseases, Biomedical Research and Therapeutic Vaccines Institute, Ciudad, Bolivar, Venezuela.ORCID 0000-0001-9131-7852
Emilia M SordilloDepartment of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7787-3051
Lourdes A Delgado-NogueraInstituto de Investigaciones Biomédicas IDB/Emerging Pathogens Network-Incubadora Venezolana de la Ciencia, Cabudare, Venezuela.ORCID 0000-0003-0910-5434
Luis A Perez-GarciaInstituto de Investigaciones Biomédicas IDB/Emerging Pathogens Network-Incubadora Venezolana de la Ciencia, Cabudare, Venezuela.ORCID 0000-0002-2230-3171
Carlos G Morantes RodríguezPsychiatry Department, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0001-9079-8375
María Eugenia LandaetaDepartment of Infectious Diseases, University Hospital of Caracas, Caracas, Venezuela.ORCID 0000-0001-9295-7296
Alberto E Paniz-MondolfiDepartment of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-1259-1736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous reports of neuropsychiatric symptoms highlighted the pathologic potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its relationship the onset and/or exacerbation of mental disease. However, coronavirus disease 2019 (COVID-19) treatments, themselves, must be considered as potential catalysts for new-onset neuropsychiatric symptoms in COVID-19 patients. To date, immediate and long-term neuropsychiatric complications following SARS-CoV-2 infection are currently unknown. Here we report on five patients with SARS-CoV-2 infection with possible associated neuropsychiatric involvement, following them clinically until resolution of their symptoms. We will also discuss the contributory roles of chloroquine and dexamethasone in these neuropsychiatric presentations.

Indexed as

COVID-19COVID-19 Drug TreatmentMental DisordersChloroquineHumansSARS-CoV-2ChloroquinechloroquinecorticosteroidsCOVID-19neuropsychiatricSARS-CoV-2

Identifiers

PMID34755347
PMCPMC8661670

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.