Evidence map›Paper›PMID 34755292›Full record

ArticleBrain imaging and behavior2022

The human raphe-hippocampal tract and affective sensitivity: a probabilistic tractography study.

Ashley E Sekul, Toshikazu Ikuta

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Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Ashley E SekulDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Toshikazu IkutaDepartment of Communication Sciences, University of Mississippi, Oxford, MS, 38655, USA. tikuta@olemiss.edu.ORCID http://orcid.org/0000-0003-0848-302X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonergic system plays critical roles in modulating affective control. The raphe nucleus has been known to be the origin of forebrain 5-HT afferents. Specifically, the Raphe-Hippocampal projection has been shown to modulate affective sensitivity in rodents. However, the human Raphe-Hippocampal tract is not well studied. We aimed to segment the Raphe-Hippocampal tract using probabilistic tractography on diffusion tensor imaging data from 502 subjects. The Raphe-Hippocampal tracts were successfully isolated in 464 individuals. There was a significant association between integrity of the Raphe-Hippocampal tract and affective sensitivity. To our best knowledge, this is the first study that isolated the human Raphe-Hippocampal tract. The integrity of the tract showed consistent characteristics with rodent findings, where affective sensitivity is modulated by the Raphe-Hippocampal projection. This study provides a technique to segment the human Raphe-Hippocampal tract and a translational knowledge that the tract in a human possesses consistent characteristics that have been found in rodent studies.

Indexed as

Diffusion Tensor ImagingMagnetic Resonance ImagingHippocampusHumansRaphe NucleiAffective sensitivityDiffusion tensor imagingDTIHippocampusProbabilistic tractographyRaphe nucleusSerotonergic pathway

Identifiers

PMID34755292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.