ArticleCell reports. Medicine2021
Multiplexed imaging reveals an IFN-γ-driven inflammatory state in nivolumab-associated gastritis.
Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- A systematic review of gastritis as an immune-related adverse event in clinical interventions.Human vaccines & immunotherapeutics · 2024Pooled it
- Clinical Characteristics and Outcomes of Pembrolizumab Induced Gastritis: A Systematic Review of the Literature.Journal of gastrointestinal cancer · 2024Pooled it
- Role of innate immunity in the development of cancer immunotherapy immune-mediated adverse events.Frontiers in immunology · 2026Review
- Pharmacovigilance study of the frequency of gastrointestinal ulceration reports associated with immune checkpoint inhibitors: insights from the FDA adverse event reporting system.Frontiers in pharmacology · 2025Article
- Neuroimmunophysiology of the gastrointestinal tract.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Drug-induced mucosal alterations observed during esophagogastroduodenoscopy.World journal of gastroenterology · 2024Review
- Immune checkpoint inhibitor-associated gastritis: Patterns and management.World journal of gastroenterology · 2024Article
- Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis.Investigational new drugs · 2024Article
- Pathobiology of Candida auris infection analyzed by multiplexed imaging and single cell analysis.PloS one · 2024Article
- An end-to-end workflow for multiplexed image processing and analysis.Nature protocols · 2023Review
- Nivolumab-induced tumour-like gastritis: A case report.World journal of clinical cases · 2023Article
- Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology.Seminars in immunopathology · 2023Review
- Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease.Seminars in immunopathology · 2023Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Immune checkpoint blockade using PD-1 inhibition is an effective approach for treating a wide variety of cancer subtypes. While lower gastrointestinal (GI) side effects are more common, upper gastrointestinal adverse events are rarely reported. Here, we present a case of nivolumab-associated autoimmune gastritis. To elucidate the immunology underlying this condition, we leverage multiplexed ion beam imaging by time-of-flight (MIBI-TOF) to identify the presence and proportion of infiltrating immune cells from a single section of biopsy specimen. Using MIBI-TOF, we analyze formalin-fixed, paraffin-embedded human gastric tissue with 28 labels simultaneously. Our analyses reveal a gastritis characterized by severe mucosal injury, interferon gamma (IFN-γ)-producing gastric epithelial cells, and mixed inflammation that includes CD8 and CD4 T cell infiltrates with reduced expression of granzyme B and FOXP3, respectively. Here, we provide a comprehensive multiplexed histopathological mapping of gastric tissue, which identifies IFN-γ-producing epithelial cells as possible contributors to the nivolumab-associated gastritis.
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