Evidence map›Paper›PMID 34755127›Full record

ArticleCell reports. Medicine2021

Mike Lange, Georgia Angelidou, Zhixu Ni, Angela Criscuolo, Jürgen Schiller, Matthias Blüher, Maria Fedorova

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Selective Editing and Functionalization of the Mammalian Lipidome.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
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  18. Article
  19. Article
  20. Observational

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mike LangeInstitute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Georgia AngelidouInstitute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Zhixu NiInstitute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Angela CriscuoloInstitute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Jürgen SchillerInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Leipzig, Germany.
Matthias BlüherMedical Department III (Endocrinology, Nephrology and Rheumatology), University of Leipzig, Leipzig, Germany.
Maria FedorovaInstitute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Leipzig University · DEHelmholtz Zentrum München · DEThermo Fisher Scientific (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodeling at the molecular level, we provide in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. We generate a human WAT reference lipidome by performing tissue-tailored preanalytical and analytical workflows, which allow accurate identification and semi-absolute quantification of 1,636 and 737 lipid molecular species, respectively. Deep lipidomic profiling allows identification of main lipid (sub)classes undergoing depot-/phenotype-specific remodeling. Previously unanticipated diversity of WAT ceramides is now uncovered.

Indexed as

LipidomicsAdipose Tissue, WhiteAgedCalibrationCeramidesChemical FractionationEthanolaminesFatty Acids, UnsaturatedFemaleHumansLipidsMaleMiddle AgedPhenotypePlasmalogensTriglyceridesCeramidesEthanolaminesFatty Acids, UnsaturatedLipidsPlasmalogenssphingadienineTriglyceridesceramideshuman white adipose tissueLC-MS/MSlipid identificationlipid metabolismlipidomicsobesityplasmalogenssemi-absolute lipid quantificationsphingolipidssubcutaneous white adipose tissuetriacylglycerolsvisceral white adipose tissue

Identifiers

PMID34755127
PMCPMC8561168
OpenAlexW3200831264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.