ArticleAnnals of gastroenterological surgery2021
Is proximal gastrectomy indicated for locally advanced cancer in the upper third of the stomach?
Article in Annals of gastroenterological surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Reflux and stenosis after minimally invasive proximal gastrectomy with double-flap technique: risk factors and impact of robotic surgery.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Therapeutic Value of Dissecting Distal Lymph Nodes in Proximal Gastric Cancer: A TVI-Based Risk Stratification.Journal of gastrointestinal cancer · 2026Article
- Is Laparoscopic/Robotic Total Gastrectomy a Reasonable and Adequate Treatment for Proximal Advanced Gastric Cancer?Annals of gastroenterological surgery · 2026Review
- Function-preserving surgery in gastric cancer: current evidence and implications for the West.World journal of surgical oncology · 2025Review
- Relationship Between Kyphosis and Postoperative Gastroesophageal Reflux After Proximal Gastrectomy.Annals of gastroenterological surgery · 2025Article
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- Comparison of clinical efficacy between π-shaped esophagojejunostomy and overlap method in treating upper gastric cancer with double-tract reconstruction in proximal gastrectomy under total laparoscopy.World journal of surgical oncology · 2025Article
- Efficacy of fluorouracil combined with paclitaxel and oxaliplatin for the treatment of advanced gastric signet ring cell carcinoma.World journal of gastrointestinal surgery · 2025Article
- Updated Review of Proximal Gastrectomy for Gastric Cancer or Cancer of the Gastroesophageal Junction.Journal of gastric cancer · 2025Review
- Long-term survival outcomes of proximal gastrectomy versus total gastrectomy in patients with T2-3 esophagogastric junction adenocarcinoma and upper third gastric adenocarcinoma: a propensity score-matching analysis.Gastroenterology report · 2025Article
- Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis.Oncology letters · 2024Article
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- Risk factors and clinical significance of lower perigastric lymph node metastases in Siewert type II and III esophagogastric junction adenocarcinoma: a retrospective cohort study.Surgical endoscopy · 2024Article
- Oncological relevance of proximal gastrectomy in advanced gastric cancer of upper third of the stomach.Surgery open science · 2024Review
- Oncological risk of proximal gastrectomy for proximal advanced gastric cancer after neoadjuvant chemotherapy.BMC cancer · 2024Article
- Review
- Indications and technical aspects of proximal gastrectomy.Frontiers in surgery · 2023Review
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- Long-term nutritional status after total gastrectomy was comparable to proximal gastrectomy but with much less reflux esophagitis and anastomotic stenosis.Frontiers in oncology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo treat upper third gastric cancer, proximal gastrectomy (PG), a function-preserving procedure, is recommended for early lesions when at least half the distal stomach can be preserved, while total gastrectomy (TG) is standard for locally advanced lesions. Oncological feasibility, when applying PG for such lesions, remains unknown.
methodsWe reviewed patients undergoing TG for clinical (c) T2-T4 upper third gastric cancer between 2006 and 2015. Preoperative tumor locations were further classified into the cardia, fornix, and gastric body based on endoscopic findings. The metastatic rate and therapeutic value index for lymph node (LN) dissection were determined, and characteristics of patients with distal LN (No. 4d, 5, and 6) metastasis (DLNM) were reviewed. In addition, patients with pathological tumor invasion to the middle third (M) region were investigated.
resultsWe studied 167 patients. There were 8 (4.8%) with DLNM and 41 (24.6%) with pathological tumor invasion to the M region. As to regional stations, therapeutic indices for LN dissection at stations No. 4d, 5, 6, and 12a were zero or extremely low. No DLNM was detected in cT2 lesions or cT3/T4 lesions located within the cardia and/or the fornix. In addition, none of the lesions located within the cardia and/or the fornix by preoperative endoscopy extended to the M region in the pathological specimen.
conclusionsFor upper third gastric cancer, PG without No. 12a dissection might be acceptable for cT2-T4 lesions located within the cardia and/or the fornix when considering the risk of DLNM and cancer-positivity in the distal stump.
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