Evidence map›Paper›PMID 34754989›Full record

ArticleJACC. Basic to translational science

Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction.

Min Gyu Kang, Bon-Kwon Koo, Udaya S Tantry, Kyehwan Kim, Jong-Hwa Ahn, Hyun Woong Park, Jeong Rang Park, Seok-Jae Hwang, Jin-Yong Hwang, Paul A Gurbel and 3 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI-A Proof-of-Concept Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Circulating Biomarkers in Coronary Microvascular Dysfunction.Journal of the American Heart Association · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
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  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Min Gyu KangDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Bon-Kwon KooDepartment of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.
Udaya S TantrySinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
Kyehwan KimDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Jong-Hwa AhnDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Hyun Woong ParkDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Jeong Rang ParkDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Seok-Jae HwangDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Jin-Yong HwangDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Paul A GurbelSinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
Habib SamadyDivision of Cardiology, Department of Medicine, Andreas Gruentzig Cardiovascular Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Jin-Sin KohDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Young-Hoon JeongDepartment of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Gyeongsang National University Hospital · KRChangwon National University · KRSinai Hospital · USEmory University · USGyeongsang National University · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between thrombogenicity and coronary microvascular dysfunction (CMD) has been poorly explored in patients with acute myocardial infarction (AMI). In our real-world clinical practice (N = 116), thrombogenicity was evaluated with thromboelastography and conventional hemostatic measures, and CMD was defined as index of microcirculatory resistance of >40 U using the invasive physiologic test. High platelet-fibrin clot strength (P-FCS) (≥68 mm) significantly increased the risk of postprocedural CMD (odds ratio: 4.35; 95% CI: 1.74-10.89). Patients with both CMD and high P-FCS had a higher rate of ischemic events compared to non-CMD subjects with low P-FCS (odds ratio: 5.58; 95% CI: 1.31-23.68). This study showed a close association between heightened thrombogenicity and CMD and their prognostic implications after reperfusion in acute myocardial infarction patients.

Indexed as

acute myocardial infarctionAMI, acute myocardial infarctioncardiovascular eventCFR, coronary flow reserveclot strengthCMD, coronary microvascular dysfunctioncoronary microvascular dysfunctionIMR, index of microcirculatory resistanceLASSO, least absolute shrinkage and selection operatorMACE, major adverse cardiovascular eventsMA, maximum amplitudeOR, odds ratioPCI, percutaneous coronary interventionP-FCS, platelet-fibrin clot strengthPRU, P2Y12 reaction unitsR, reaction timeTEG, thromboelastographythrombogenicityTIMI, Thrombolysis in Myocardial InfarctionTmn, mean transit time

Identifiers

PMID34754989
PMCPMC8559320
OpenAlexW3209219977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.