Evidence map›Paper›PMID 34754516›Full record

ArticleInternational journal of Alzheimer's disease2021

Validation of AD8-Philippines (AD8-P): A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines.

Jacqueline C Dominguez, Ma Fe P de Guzman, Ma Lourdes C Joson, Krizelle Fowler, Boots P Natividad, Precy S Cruz, Jose Leo Jiloca, Primitivo B Mactal, Jayvee Dyne Dominguez, Jeffrey Domingo and 6 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of Alzheimer's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Development and validation of the Ascertain Dementia 8 (AD8) Thai version.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Jacqueline C DominguezInstitute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.ORCID https://orcid.org/0000-0003-2017-7797
Ma Fe P de GuzmanInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Ma Lourdes C JosonInstitute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.ORCID https://orcid.org/0000-0002-4859-8887
Krizelle FowlerInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Boots P NatividadInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Precy S CruzInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Jose Leo JilocaInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Primitivo B MactalInstitute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.
Jayvee Dyne DominguezInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Jeffrey DomingoInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Jhozel Kim Dominguez-AwaoInstitute for Dementia Care Asia, Quezon City 1102, Philippines.
Macario ReandelarResearch and Biotechnology Division, St. Luke's Medical Center, Quezon City 1102, Philippines.
Jem R JavierDepartment of Linguistics, College of Social Sciences and Philosophy, University of the Philippines, Quezon City 1100, Philippines.
ThienKieuThi PhungDepartment of Neurology, Danish Dementia Research Center, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark.
John C MorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, USA.
St. Luke's Medical Center · PHSaint Louis University · PHUniversity of Copenhagen · DKUniversity of Miami · USUniversity of the Philippines System · PHWashington University in St. Louis · US

Funding

Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2021 to 2025
$13.8M
NIA NIH HHS R01 AG071514
6 · The paper itself

Abstract

aimThis study was aimed at validating the Filipino version of AD8 (AD8-P).

methodsCommunity-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia.

resultsA total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3.

conclusionAD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.

Identifiers

PMID34754516
PMCPMC8572610
OpenAlexW3211124152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.