ArticleEvolution, medicine, and public health2021
Evolutionary selection of alleles in the melanophilin gene that impacts on prostate organ function and cancer risk.
Article in Evolution, medicine, and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Inferring past demography and genetic adaptation in Spain using the GCAT cohort.Scientific reports · 2025Article
- Melanophilin Polymorphism in Ferrets of Different Color.Doklady. Biochemistry and biophysics · 2023Article
- The adaptive evolution of cancer driver genes.BMC genomics · 2023Article
- FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture.MethodsX · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectivesSeveral hundred inherited genetic variants or SNPs that alter the risk of cancer have been identified through genome-wide association studies. In populations of European ancestry, these variants are mostly present at relatively high frequencies. To gain insight into evolutionary origins, we screened a series of genes and SNPs linked to breast or prostate cancer for signatures of historical positive selection. METHODOLOGY: We took advantage of the availability of the 1000 genome data and we performed genomic scans for positive selection in five different Caucasian populations as well as one African reference population. We then used prostate organoid cultures to provide a possible functional explanation for the interplay between the action of evolutionary forces and the disease risk association.
resultsVariants in only one gene showed genomic signatures of positive, evolutionary selection within Caucasian populations melanophilin ( CONCLUSIONS AND IMPLICATIONS: The LAY SUMMARY: We screened a limited series of genomic variants associated with breast and prostate cancer risk for signatures of historical positive selection. Variants within the melanophilin (
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