Evidence map›Paper›PMID 34754450›Full record

ArticleClinical & translational immunology2021

IFN-γ facilitates liver fibrogenesis by CD161

Jing Li, Lisha Cheng, Haoyu Jia, Chun Liu, Siqi Wang, Yun Liu, Yue Shen, Shengdi Wu, Fanli Meng, Beishi Zheng and 2 more

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Elevated Peripheral CD161ACR open rheumatology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Intrahepatic CD161Immunity, inflammation and disease · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. A TNature aging · 2023
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Jing LiDepartment of Gastroenterology and Hepatology Tongji Hospital School of Medicine Tongji University Shanghai China.
Lisha ChengDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Haoyu JiaDepartment of Gastroenterology and Hepatology Tongji Hospital School of Medicine Tongji University Shanghai China.
Chun LiuDepartment of Gastroenterology and Hepatology Tongji Hospital School of Medicine Tongji University Shanghai China.
Siqi WangDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Yun LiuDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Yue ShenDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Shengdi WuDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Fanli MengDepartment of Hepatology Qilu Hospital Shandong University Shandong China.
Beishi ZhengDepartment of Internal Medicine Woodhull Medical Center New York NY USA.
Changqing YangDepartment of Gastroenterology and Hepatology Tongji Hospital School of Medicine Tongji University Shanghai China.
Wei JiangDepartment of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China.
Tongji Hospital · CNFudan University · CNSun Yat-sen University · CNZhongshan Hospital · CNQilu Hospital of Shandong University · CNTongji University · CNWoodhull Medical and Mental Health Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to determine the role of CD161

methodsA total of 94 patients with chronic hepatitis B (CHB), 73 with liver cirrhosis (LC) and 28 healthy controls were enrolled to determine frequency, cytokine production and chemokine receptor expression of circulating CD161

resultsCD161

conclusionsIn chronic HBV infection, CD161

Indexed as

CD161+CD4+ T cellsHBVinterferon‐γinterleukin 17liver fibrosis

Identifiers

PMID34754450
PMCPMC8563156
OpenAlexW3210738553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.