Evidence map›Paper›PMID 34754406›Full record

ArticleUpsala journal of medical sciences2021

Elevated gaseous luminal nitric oxide and circulating IL-8 as features of

Hiwa K Saaed, Lisa Chiggiato, Dominic-Luc Webb, Ann-Sofie Rehnberg, Carlos A Rubio, Ragnar Befrits, Per M Hellström

Open access · diamondAbstract read
In one paragraph

Article in Upsala journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Immunokinetic signatures ofFrontiers in cellular and infection microbiology · 2026
    Review
  2. Review
  3. NO: a key player in microbiome dynamics and cancer pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  4. Article
  5. Article
  6. Haptoglobin in Juvenile Idiopathic Arthritis.Pediatric rheumatology online journal · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hiwa K SaaedDepartment of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden.
Lisa ChiggiatoDepartment of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden.
Dominic-Luc WebbDepartment of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden.
Ann-Sofie RehnbergDepartment of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden.
Carlos A RubioDepartment of Pathology, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden.
Ragnar BefritsDepartment of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden.
Per M HellströmDepartment of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric nitric oxide (NO) production in response to MATERIALS AND

methodsEsophagogastroduodenoscopy was done in 96 dyspepsia patients. Luminal [NO] was measured by chemiluminescence. Biopsies were taken from gastric antrum and corpus for culture and histopathology.

results

conclusionsOf the parameters tested, increased gastric [NO] and circulating IL-8 align most consistently and selectively in

Indexed as

Helicobacter InfectionsHelicobacter pyloriGasesGastric MucosaHumansInflammationInterleukin-8Nitric OxideGasesInterleukin-8Nitric OxidebiomarkerscytokinesHelicobacter pyloriinflammationNitric oxide

Identifiers

PMID34754406
PMCPMC8559587
OpenAlexW3205464716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.