ArticleWorld journal of gastrointestinal surgery2021
Low serum albumin may predict poor efficacy in patients with perforated peptic ulcer treated nonoperatively.
Article in World journal of gastrointestinal surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Development of a Scoring System to Predict the Treatment Success for Nonoperative Management of Peptic Ulcer Perforation: A Secondary Data Analysis of PPAP Study.Annals of gastroenterological surgery · 2026Article
- Development of a Prognostic Model for Prolonged Hospital Stay After Gastrointestinal Perforation Surgery.International journal of general medicine · 2026Article
- Prognostic risk factors in upper gastrointestinal perforation: the role of body composition parameters.Frontiers in nutrition · 2025Article
- Assessing peptic ulcer risk with the HAMPROW score in the general Chinese population.Scientific reports · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundNonoperative management (NOM) is a promising therapeutic modality for patients with perforated peptic ulcer (PPU). However, the risk factors for poor efficacy and adverse events of NOM are a concern.
aimTo investigate the factors predictive of poor efficacy and adverse events in patients with PPU treated by NOM.
methodsThis retrospective case-control study enrolled 272 patients who were diagnosed with PPU and initially managed nonoperatively from January 2014 to December 2018. Of these 272 patients, 50 converted to emergency surgery due to a lack of improvement (surgical group) and 222 patients were included in the NOM group. The clinical data of these patients were collected. Baseline patient characteristics and adverse outcomes were compared between the two groups. Logistic regression analysis and receiver operating characteristic curve analyses were conducted to investigate the factors predictive of poor efficacy of NOM and adverse outcomes in patients with PPU.
resultsAdverse outcomes were observed in 71 patients (32.0%). Multivariate analyses revealed that low serum albumin level was an independent predictor for poor efficacy of NOM and adverse outcomes in patients with PPU.
conclusionLow serum albumin level may be used as an indicator to help predict the poor efficacy of NOM and adverse outcomes, and can be used for risk stratification in patients with PPU.
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