Evidence map›Paper›PMID 34754155›Full record

ReviewWorld journal of gastroenterology2021

Endoscopic anti-reflux therapy for gastroesophageal reflux disease.

Enrique Rodríguez de Santiago, Eduardo Albéniz, Fermin Estremera-Arevalo, Carlos Teruel Sanchez-Vegazo, Vicente Lorenzo-Zúñiga

Registry-linked trialAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05899491 (Role of ARMA in Selective Subset of Refractory GERD Patients- A Randomized Sham Control Trial.), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05899491 nacompletednot on this mapstarted 2023, after this paper: background citation

Role of ARMA in Selective Subset of Refractory GERD Patients- A Randomized Sham Control Trial.

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2023 to 2023Enrolled50ConditionsGERD, Reflux, Reflux EsophagitisArmsARMA, UGI Endoscopy
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Efficacy and Safety of Closure-Focused Anti-Reflux Mucoplasty Compared With Conventional ARMS: A Propensity Score-Matched Study (With Video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Article
  2. Article
  3. Article
  4. Reflux Esophagitis.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  5. Review
  6. Review
  7. Problems with repairing gut sphincters malfunctions.World journal of gastrointestinal surgery · 2024
    Article
  8. Pilot study on anti-reflux mucoplasty: Advancing endoscopic anti-reflux therapy for gastroesophageal reflux disease.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Clinical efficacy of endoscopic antireflux mucosectomyAnnals of translational medicine · 2022
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Enrique Rodríguez de SantiagoDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain. enrodesan@gmail.com.
Eduardo AlbénizEndoscopy Unit, Gastroenterology Department, Hospital Universitario de Navarra. Gastrointestinal Endoscopy Research Unit, Navarrabiomed Biomedical Research Center. Pamplona, Spain.
Fermin Estremera-ArevaloEndoscopy Unit, Gastroenterology Department, Hospital Universitario de Navarra. Gastrointestinal Endoscopy Research Unit, Navarrabiomed Biomedical Research Center. Pamplona, Spain.
Carlos Teruel Sanchez-VegazoDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain.
Vicente Lorenzo-ZúñigaEndoscopy Unit, Gastroenterology Department, Hospital Universitari i Politècnic La Fe, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia 46026, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide. A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse effects. Endoscopic anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong medication. The best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal hernia. Transoral incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical trials. Band-assisted ligation techniques, anti-reflux mucosectomy, anti-reflux mucosal ablation, and new plication devices have yielded promising results in recent noncontrolled studies. Nonetheless, the role of endoscopic procedures remains controversial due to limited long-term and comparative data, and no consensus exists in current clinical guidelines. This review provides an updated summary focused on the patient selection, technical details, clinical success, and safety of current and future endoscopic anti-reflux techniques.

Indexed as

Esophagitis, PepticGastroesophageal RefluxProton Pump InhibitorsFundoplicationHumansTreatment OutcomeProton Pump InhibitorsAnti-reflux mucosal ablationAnti-reflux mucosectomyGastroesophageal refluxStrettaTransoral incisionless fundoplicationTreatment

Identifiers

PMID34754155
PMCPMC8554403

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.