Evidence map›Paper›PMID 34754047›Full record

Observational studyScientific reports2021

Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization.

Sato Uematsu, Hirokazu Sakaguchi, Kaori Sayanagi, Yasushi Ikuno, Ayako Yokoyama, Tomoko Asai, Yoko Fukushima, Chikako Hara, Susumu Sakimoto, Kohji Nishida

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sato UematsuDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Hirokazu SakaguchiDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan. sakaguh@ophthal.med.osaka-u.ac.jp.
Kaori SayanagiDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Yasushi IkunoIkuno Eye Center, Osaka, Japan.
Ayako YokoyamaEye Center, Sakai City Medical Center, Sakai, Japan.
Tomoko AsaiAsai Eye Clinic, Amagasaki, Japan.
Yoko FukushimaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Chikako HaraDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Susumu SakimotoDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Osaka University · JPHyogo Brain and Heart Center · JPItami City Hospital · JPSakai Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, no reports are investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude-decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Six eyes (18.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P < 0.001). CFD around CNV was observed in 24 eyes (72.7%), including all active cases (11 cases) and 13 (59.1%) of 22 inactive cases. CFD size correlated significantly with CNV activity (P < 0.001). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.

Indexed as

Regional Blood FlowAdultAgedAged, 80 and overAngiogenesis InhibitorsChoroidChoroidal NeovascularizationFemaleFluorescein AngiographyHumansMaleMiddle AgedMyopiaRetrospective StudiesTomography, Optical CoherenceVascular Endothelial Growth Factor AAngiogenesis InhibitorsVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID34754047
PMCPMC8578547
OpenAlexW3133753044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.