Evidence map›Paper›PMID 34753963›Full record

ArticleScientific reports2021

Uncovering associations between data-driven learned qMRI biomarkers and chronic pain.

Alejandro G Morales, Jinhee J Lee, Francesco Caliva, Claudia Iriondo, Felix Liu, Sharmila Majumdar, Valentina Pedoia

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Artificial intelligence in musculoskeletal applications: a primer for radiologists.Diagnostic and interventional radiology (Ankara, Turkey) · 2025
    Review
  4. Article
  5. Article
  6. Effects of TJournal of magnetic resonance imaging : JMRI · 2024
    Article
  7. Article
  8. The knee connectome: A novel tool for studying spatiotemporal change in cartilage thickness.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alejandro G MoralesDepartment of Bioengineering, University of California, Berkeley, USA. alegmoralesm@gmail.com.
Jinhee J LeeCenter for Intelligent Imaging, University of California, San Francisco, USA.
Francesco CalivaCenter for Intelligent Imaging, University of California, San Francisco, USA.
Claudia IriondoDepartment of Bioengineering, University of California, Berkeley, USA.
Felix LiuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Sharmila MajumdarCenter for Intelligent Imaging, University of California, San Francisco, USA.
Valentina PedoiaCenter for Intelligent Imaging, University of California, San Francisco, USA.

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVEN01AR22258 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL · 2007 to 2011
$13.5M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22259 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 2007 to 2011
$7.8M
Clinical Centers for the Osteoarthritis Initiative^Rhode IslandN01AR22262 · NIAMS · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B. · 2007 to 2010
$6.8M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH FDN · PI JACKSON, REBECCA · 2007 to 2011
$6.2M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22260 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2007 to 2010
$6.1M
Deep Learning for Characterizing Knee Joint Degeneration Predicting Progression of Osteoarthritis and Total Knee ReplacementR61AR073552 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA, PEDOIA, VALENTINA · 2018 to 2019
$871k
Multidimensional MRI-based Non-Euclidean Deep Learning to Study OsteoarthritisR00AR070902 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PEDOIA, VALENTINA · 2018 to 2020
$747k
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–
NEW PHARMACOLOGY ASPECTS RELATED TO CARBONIC ANHYDRASER01HL022258 · NHLBI · UNIVERSITY OF FLORIDA · PI MAREN, THOMAS H · 1985 to 1986
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
NHLBI NIH HHS N01AR22258NIAMS NIH HHS N01AR22259NIAMS NIH HHS N01AR22260NIAMS NIH HHS N01AR22261NIAMS NIH HHS N01AR22262NIAMS NIH HHS R00 AR070902NIAMS NIH HHS R00AR070902NIAMS NIH HHS R61 AR073552NIAMS NIH HHS R61AR073552
6 · The paper itself

Abstract

Knee pain is the most common and debilitating symptom of knee osteoarthritis (OA). While there is a perceived association between OA imaging biomarkers and pain, there are weak or conflicting findings for this relationship. This study uses Deep Learning (DL) models to elucidate associations between bone shape, cartilage thickness and T

Indexed as

BiomarkersChronic PainFemaleHumansKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneeBiomarkers

Identifiers

PMID34753963
PMCPMC8578418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.