ArticleNature communications2021
Mid-lateral cerebellar complex spikes encode multiple independent reward-related signals during reinforcement learning.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2025Review
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.Current biology : CB · 2025Article
- Striatal and cerebellar interactions during reward-based motor performance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.bioRxiv : the preprint server for biology · 2025Article
- Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.PLoS computational biology · 2025Article
- Striatal and cerebellar interactions during reward-based motor performance.bioRxiv : the preprint server for biology · 2025Article
- The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia.Cerebellum (London, England) · 2024Article
- Reinforcement Motor Learning After Cerebellar Damage Is Related to State Estimation.Cerebellum (London, England) · 2024Article
- A cerebro-cerebellar network for learning visuomotor associations.Nature communications · 2024Article
- Article
- Sensorimotor-linked reward modulates smooth pursuit eye movements in monkeys.Frontiers in neuroscience · 2023Article
- Mixed Selectivity in the Cerebellar Purkinje-Cell Response during Visuomotor Association Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Although the cerebellum has been implicated in simple reward-based learning recently, the role of complex spikes (CS) and simple spikes (SS), their interaction and their relationship to complex reinforcement learning and decision making is still unclear. Here we show that in a context where a non-human primate learned to make novel visuomotor associations, classifying CS responses based on their SS properties revealed distinct cell-type specific encoding of the probability of failure after the stimulus onset and the non-human primate's decision. In a different context, CS from the same cerebellar area also responded in a cell-type and learning independent manner to the stimulus that signaled the beginning of the trial. Both types of CS signals were independent of changes in any motor kinematics and were unlikely to instruct the concurrent SS activity through an error based mechanism, suggesting the presence of context dependent, flexible, multiple independent channels of neural encoding by CS and SS. This diversity in neural information encoding in the mid-lateral cerebellum, depending on the context and learning state, is well suited to promote exploration and acquisition of wide range of cognitive behaviors that entail flexible stimulus-action-reward relationships but not necessarily motor learning.
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