ArticleNature communications2021
Diet composition influences the metabolic benefits of short cycles of very low caloric intake.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Yeast Chronological Lifespan Model as a Tool for Screening Aging Interventions.International journal of molecular sciences · 2026Review
- Preoperative gut microbial and metabolic signatures associated with postoperative Hirschsprung-associated enterocolitis in short-segment Hirschsprung disease.Frontiers in microbiology · 2026Article
- Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice.BMC biology · 2024Article
- Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention.Nature communications · 2024Article
- The different association between fat mass distribution and intake of three major nutrients in pre- and postmenopausal women.PloS one · 2024Article
- Physical activity of mice on dietary sulfur amino acid restriction is influenced by age of diet initiation and biological sex.Scientific reports · 2023Article
- Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.Cell metabolism · 2023Article
- Dynamics and ecological reassembly of the human gut microbiome and the host metabolome in response to prolonged fasting.Frontiers in microbiology · 2023Article
- Review
- Review
- Diet composition influences the metabolic benefits of short cycles of very low caloric intake.Nature communications · 2021Article
- Religious fasting and the vascular health.Indian heart journalArticle
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Diet composition, calories, and fasting times contribute to the maintenance of health. However, the impact of very low-calorie intake (VLCI) achieved with either standard laboratory chow (SD) or a plant-based fasting mimicking diet (FMD) is not fully understood. Here, using middle-aged male mice we show that 5 months of short 4:10 VLCI cycles lead to decreases in both fat and lean mass, accompanied by improved physical performance and glucoregulation, and greater metabolic flexibility independent of diet composition. A long-lasting metabolomic reprograming in serum and liver is observed in mice on VLCI cycles with SD, but not FMD. Further, when challenged with an obesogenic diet, cycles of VLCI do not prevent diet-induced obesity nor do they elicit a long-lasting metabolic memory, despite achieving modest metabolic flexibility. Our results highlight the importance of diet composition in mediating the metabolic benefits of short cycles of VLCI.
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