ArticleTranslational psychiatry2021
Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- Perinatal Factors and Neuroimaging Changes for Brain Maturation Among Adolescents.JAMA network open · 2026Article
- Assessing the Psychometric Properties of the Child Behaviour Checklist in the ABCD Study.Developmental science · 2026Article
- Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.JCPP advances · 2026Article
- Machine-Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prediction of mental health risk in adolescents.Nature medicine · 2025Article
- Impathy and Emotion Recognition: How Attachment Shapes Self- and Other-Focused Emotion Processing.Brain sciences · 2025Article
- Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents.Journal of mood and anxiety disorders · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children.Developmental cognitive neuroscience · 2023Article
- Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Neurobiological, familial and genetic risk factors for dimensional psychopathology in the Adolescent Brain Cognitive Development study.Molecular psychiatry · 2022Article
Corrections and comments
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Authors and funding
12 authors.
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Abstract
Convergent research identifies a general factor ("P factor") that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); p
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