Evidence map›Paper›PMID 34753819›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Functional alterations in cortical processing of speech in glioma-infiltrated cortex.

Alexander A Aabedi, Benjamin Lipkin, Jasleen Kaur, Sofia Kakaizada, Claudia Valdivia, Sheantel Reihl, Jacob S Young, Anthony T Lee, Saritha Krishna, Mitchel S Berger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander A AabediDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.ORCID 0000-0002-7935-5458
Benjamin LipkinDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109.ORCID 0000-0001-7465-5315
Jasleen KaurDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Sofia KakaizadaDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Claudia ValdiviaDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Sheantel ReihlDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Jacob S YoungDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.ORCID 0000-0002-5499-4325
Anthony T LeeDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Saritha KrishnaDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Mitchel S BergerDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143.
David BrangDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109 shawn.hervey-jumper@ucsf.edu djbrang@umich.edu.ORCID 0000-0002-2706-6777
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, CA, 94143; shawn.hervey-jumper@ucsf.edu djbrang@umich.edu.

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III gliomaK08NS110919 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERVEY-JUMPER, SHAWN L. · 2019 to 2023
$1.0M
Networks Underlying Visual Modulation of Speech PerceptionR00DC013828 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRANG, DAVID · 2016 to 2018
$747k
NCI NIH HHS L30 CA199570NCI NIH HHS P50 CA097257NIDCD NIH HHS R00 DC013828NINDS NIH HHS K08 NS110919
6 · The paper itself

Abstract

Recent developments in the biology of malignant gliomas have demonstrated that glioma cells interact with neurons through both paracrine signaling and electrochemical synapses. Glioma-neuron interactions consequently modulate the excitability of local neuronal circuits, and it is unclear the extent to which glioma-infiltrated cortex can meaningfully participate in neural computations. For example, gliomas may result in a local disorganization of activity that impedes the transient synchronization of neural oscillations. Alternatively, glioma-infiltrated cortex may retain the ability to engage in synchronized activity in a manner similar to normal-appearing cortex but exhibit other altered spatiotemporal patterns of activity with subsequent impact on cognitive processing. Here, we use subdural electrocorticography to sample both normal-appearing and glioma-infiltrated cortex during speech. We find that glioma-infiltrated cortex engages in synchronous activity during task performance in a manner similar to normal-appearing cortex but recruits a diffuse spatial network. On a temporal scale, we show that signals from glioma-infiltrated cortex have decreased entropy, which may affect its ability to encode information during nuanced tasks such as production of monosyllabic versus polysyllabic words. Furthermore, we show that temporal decoding strategies for distinguishing monosyllabic from polysyllabic words were feasible for signals arising from normal-appearing cortex but not from glioma-infiltrated cortex. These findings inform our understanding of cognitive processing in chronic disease states and have implications for neuromodulation and prosthetics in patients with malignant gliomas.

Indexed as

AdultBrain NeoplasmsCerebral CortexElectrocorticographyGliomaHumansNeuronsSpeechTemporal Lobegliomaglioma electrophysiologyneural circuitryneural decodingspeech

Identifiers

PMID34753819
PMCPMC8609626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.