Evidence map›Paper›PMID 34753606›Full record

ReviewTrends in neurosciences2022

MicroRNA regulation of critical retinal pigment epithelial functions.

Samuel W Du, Krzysztof Palczewski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Autophagy in ocular diseases: from mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samuel W DuCenter for Translational Vision Research, University of California, Irvine School of Medicine, CA, USA; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine School of Medicine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine School of Medicine, CA, USA.
Krzysztof PalczewskiCenter for Translational Vision Research, University of California, Irvine School of Medicine, CA, USA; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine School of Medicine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine School of Medicine, CA, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine School of Medicine, CA, USA; Department of Chemistry, University of California, Irvine School of Medicine, CA, USA. Electronic address: kpalczew@uci.edu.

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
microRNA-204 and microRNA-211 regulation of RPE phagocytosisF30EY033642 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Samuel Wang Du · 2022 to 2026
$241k
NEI NIH HHS F30 EY033642NEI NIH HHS R01 EY009339NEI NIH HHS R24 EY027283NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

MicroRNAs are short, evolutionarily conserved noncoding RNAs that are critical for the control of normal cellular physiology. In the retina, photoreceptors are highly specialized neurons that transduce light into electrical signals. Photoreceptors, however, are unable to process visual stimuli without the support of the retinal pigment epithelium (RPE). The RPE performs numerous functions to aid the retina, including the generation of visual chromophore and metabolic support. Recent work has underscored how microRNAs enable vision through their contributions to RPE functions. This review focuses on the biogenesis and control of microRNAs in rodents and humans, the roles microRNAs play in RPE function and degeneration, and how microRNAs could serve as potential therapeutics and biomarkers for visual diseases.

Indexed as

MicroRNAsHumansRetinaRetinal Pigment EpitheliumRetinal PigmentsVision, OcularMicroRNAsRetinal Pigmentsbiomarkerexosomegene therapynoncoding RNAoxidative stressphagocytosis

Identifiers

PMID34753606
PMCPMC9066699

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.