ArticleEmerging microbes & infections2021
Prevalence and risk factors of active tuberculosis in patients with rheumatic diseases: a multi-center, cross-sectional study in China.
Open access · goldAbstract readMulticenter Study
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Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Incidence and prevalence of tuberculosis in systemic lupus erythematosus patients: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
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- Utility of CBC-derived ratios in the diagnosis and prediction of active tuberculosis in people with rheumatic diseases.BMC infectious diseases · 2026Article
- Case Report: delayed recognition of pulmonary tuberculosis during immunosuppression for suspected connective tissue disease.Frontiers in medicine · 2026Article
- Article
- Risk Factors of Progression to Active Tuberculosis in Rheumatic Patients With Latent Tuberculosis: A Retrospective Study.Immunity, inflammation and disease · 2025Article
- Diagnostic accuracy of T-SPOT.TB and TST in detecting active tuberculosis in patients with rheumatic immune diseases: a fully matched comparative study.BMC infectious diseases · 2025Article
- Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study.BMJ open · 2025Article
- Effectiveness of tuberculosis preventive treatment in patients with rheumatic diseases: a global systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Clinical Characteristics and Mortality Risk Factors in Patients with Tuberculosis and CoincidentInfection and drug resistance · 2025Article
- Epidemiology of Latent Tuberculosis in Rheumatic Immune-Mediated Inflammatory Diseases-Study of 1117 Patients and Descriptive Literature Review.Journal of clinical medicine · 2024Article
- The Long-Term Journey of a Tuberculosis Patient With Triple Organ Involvement and Rheumatological Disease: A Case Study and Literature Review.Clinical case reports · 2024Article
- Incidence, risk factors for active tuberculosis infection and changes of IGRA in patients with Takayasu arteritis: a prospective cohort study.Emerging microbes & infections · 2024Article
- Suitability of reduced dose glucocorticoids therapy regimen for antibody-associated vasculitis patients with TB: a retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Knowledge and Attitudes About Screening and Preventive Treatment of Latent Tuberculosis Infection Among Patients with Rheumatic Diseases in Beijing, China.Infection and drug resistance · 2024Article
- Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study.Microbiology spectrum · 2023Article
- Latent tuberculosis infection in myasthenia gravis patients on immunosuppressive therapy: high incidence yet moderate reactivation rate.Annals of medicine · 2023Article
- Incidence and risk factors of tuberculosis in systemic lupus erythematosus patients: a multi-center prospective cohort study.Frontiers in immunology · 2023Article
- Tuberculosis remains a major burden in systemic lupus erythematosus patients in Durban, South Africa.Frontiers in medicine · 2023Article
- Clinical characteristics and related influencing factors of common rheumatic diseases concomitant with tuberculosis.Frontiers in public health · 2022Article
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Authors and funding
53 authors at 14 institutions in 2 countries.
Xiaoqing LiuDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.ORCID 0000-0001-8162-0903
Lifan ZhangDivision of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Fengchun ZhangDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Xiaofeng ZengDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Yan ZhaoDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Qian WangDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Shengyun LiuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Xiaoxia ZuoDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.ORCID 0000-0002-3928-9660
Zhiyi ZhangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Huaxiang WuDepartment of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Sheng ChenDepartment of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Hongbin LiDepartment of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People's Republic of China.
Ping ZhuDepartment of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Lijun WuDepartment of Rheumatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, People's Republic of China.
Wencheng QiDepartment of Rheumatology, Tianjin First Central Hospital, Tianjin, People's Republic of China.
Yi LiuDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Miaojia ZhangDepartment of Rheumatology, The first affiliated hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Huaxiang LiuDepartment of Rheumatology, Qilu Hospital of Shandong University, Ji'nan, People's Republic of China.
Dong XuDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Wenjie ZhengDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Yueqiu ZhangDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Xiaochun ShiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Lishuai HanDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Yaou ZhouDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Yanping ZhaoDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Wenwen WangDepartment of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Ting LiDepartment of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Ning TieDepartment of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People's Republic of China.
Kui ZhangDepartment of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Cainan LuoDepartment of Rheumatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, People's Republic of China.
Baoqi GongDepartment of Rheumatology, Tianjin First Central Hospital, Tianjin, People's Republic of China.
Yi ZhaoDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Chengyin LvDepartment of Rheumatology, The first affiliated hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Lijun SongDepartment of Rheumatology, Qilu Hospital of Shandong University, Ji'nan, People's Republic of China.
Qingjun WuDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Yunyun FeiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Lei ZhangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Hui LuoDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Jiaying SunDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Jing XueDepartment of Rheumatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Liyang GuDepartment of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Jing WangDepartment of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People's Republic of China.
Qing HanDepartment of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Kuerbanjiang YimaityDepartment of Rheumatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, People's Republic of China.
Jiaxin ZhouDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Lidan ZhaoDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Sainan BianDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, People's Republic of China.
Wufang QiDepartment of Rheumatology, Tianjin First Central Hospital, Tianjin, People's Republic of China.
Yanhong LiDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Yujing ZhuDepartment of Rheumatology, The first affiliated hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Huijun HanDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People's Republic of China.
Susu LiaoDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People's Republic of China.
Gaifen LiuChina National Clinical Research Center for Neurological Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNHarbin Medical University · CNCentral South University · CNInner Mongolia Medical University · CNNanjing Medical University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNSecond Affiliated Hospital of Zhejiang University · CNShanghai Jiao Tong University · CNTianjin First Center Hospital · CNXijing Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNQilu Hospital of Shandong University · CNSichuan University · CNCapital University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence of active tuberculosis (ATB) in patients with rheumatic diseases are research priorities but limited data from China have been reported. Research targeting patients not taking anti-TNF biologics are especially insufficient. We aimed to investigate the prevalence and risk factors of ATB in this at-risk population. We conducted a tertiary hospital-based, multi-center, cross-sectional study by using stratified multi-stage cluster sampling strategy to screen ATB in patients with rheumatic diseases. We estimated the prevalence of ATB in patients with rheumatic diseases and identified risk factors among those who were not taking anti-TNF biologic. A total of 13,550 eligible patients were enrolled, and the result showed the standardized prevalence of ATB according to the composition ratio of various types of rheumatic disease was 882/100000 (95% confidence interval (CI): 706-1057). Multivariable logistic regression analysis in patients not taking anti-TNF biologics showed that the independent risk factors of ATB were having systemic lupus erythematosus (SLE) (OR=2.722, 95% CI: 1.437-5.159,
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AdultChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRheumatic DiseasesRisk FactorsTuberculosisActive tuberculosisChinaprevalencerheumatic diseaserisk factors
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