Evidence map›Paper›PMID 34753172›Full record

ArticleBlood advances2022

Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation.

Muna Qayed, Benjamin Watkins, Scott Gillespie, Brandi Bratrude, Kayla Betz, Sung W Choi, Jeffrey Davis, Christine Duncan, Roger Giller, Michael Grimley and 14 more

Abstract read
In one paragraph

Article in Blood advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Human OX40L-CAR-TScience translational medicine · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Novel approaches to acute graft-versus-host disease prevention.Hematology. American Society of Hematology. Education Program · 2023
    Review
  13. Article
  14. Article
  15. Observational
  16. Role of abatacept in the prevention of graft-Therapeutic advances in hematology · 2023
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Muna QayedAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, GA.
Benjamin WatkinsAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, GA.
Scott GillespieDepartment of Pediatrics, Emory University, Atlanta, GA.
Brandi BratrudeBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-1498-1001
Kayla BetzBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.
Sung W ChoiDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-6321-3834
Jeffrey DavisBC Children's Hospital, University of British Columbia, Vancouver, Canada.
Christine DuncanBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.
Roger GillerCenter for Cancer and Blood Disorders, Children Hospital of Colorado, University of Colorado, Aurora, CO.
Michael GrimleyUniversity of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.ORCID 0000-0003-2056-5167
Andrew C HarrisUniversity of Utah, Primary Children's Hospital, Salt Lake City, UT.ORCID 0000-0002-4538-8817
David JacobsohnChildren's National Health System, Washington, DC.
Nahal LalefarUniversity of California San Francisco, UCSF Benioff Children's Hospital Oakland, Oakland, CA.
Maxim NorkinBaptist Medical Center Jacksonville, Jacksonville, FL.
Nosha FarhadfarUniversity of Florida, UF Health Shands Hospital, Gainesville, FL.
Michael A PulsipherChildren's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, CA.ORCID 0000-0003-3030-8420
Shalini ShenoyWashington University School of Medicine, St. Louis, MO.
Aleksandra PetrovicSeattle Children's Hospital, Seattle, WA; and.
Kirk R SchultzBC Children's Hospital, University of British Columbia, Vancouver, Canada.
Gregory A YanikDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Edmund K WallerWinship Cancer Institute, Emory University, Atlanta, GA.ORCID 0000-0003-0816-6729
Amelia LangstonWinship Cancer Institute, Emory University, Atlanta, GA.ORCID 0000-0003-0649-1915
Leslie S KeanBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.
John T HoranBoston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA.

Funding

Novel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3M
Phase 2 Study of Abatacept with Calcineurin Inhibition and Methotrexate for GVHDR01FD004099 · FDA · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2013 to 2016
$1.7M
Unrelated Donor BMT vs. Immune Suppression for Newly Diagnosed Severe Aplastic Anemia in Children and Young Adults: BMT CTN Core Center Renewal for the Pediatric Blood and Marrow Transplant ConsortiumUG1HL069254 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KEAN, LESLIE S · 2017 to 2023
$1.3M
FDA HHS R01 FD004099NHLBI NIH HHS R01 HL095791NHLBI NIH HHS UG1 HL069254
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationAbataceptHumansTransplantation ConditioningUnrelated DonorsAbatacept

Identifiers

PMID34753172
PMCPMC8945296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.