Evidence map›Paper›PMID 34753145›Full record

ReviewActa haematologica2022

Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia.

Vikita Mehta, Abirami Kirubarajan, Amir Sabouhanian, Sanasi M Jayawardena, Priya Chandrakumaran, Nila Thangavelu, Refai Cader, Sachith Mettananda, Dayananda Bandara, Shawn Khan and 4 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Vikita MehtaArts and Science, McMaster University, Hamilton, Ontario, Canada.
Abirami KirubarajanFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Amir SabouhanianFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Sanasi M JayawardenaFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Priya ChandrakumaranFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Nila ThangaveluHealth Sciences, McMaster University, Hamilton, Ontario, Canada.
Refai CaderPolicy Analysis and Development, Ministry of Health, Colombo, Sri Lanka.
Sachith MettanandaDepartment of Paediatrics, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Dayananda BandaraNational Thalassaemia Centre, Kurunegala, Sri Lanka.
Shawn KhanFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
David J WeatherallMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Angela AllenMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Anuja P PremawardhenaFaculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Nancy F OlivieriPediatrics, Medicine and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAMcMaster University · CAUniversity of Kelaniya · LKUniversity of Oxford · GBNational Hospital of Sri Lanka · LKToronto Public Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeg ulcers are a frequent complication in patients with the inherited hemoglobin disorders. In thalassemia, the literature is limited, and factors associated with the development of leg ulcers in hemoglobin E (HbE) beta thalassemia, the most common form of severe beta-thalassemia worldwide, have not previously been reported.

methodsWe reviewed all available medical records of patients with HbE beta thalassemia to document the onset of leg ulcers at the 2 largest treatment centers in Sri Lanka. We reviewed the literature to identify studies reporting outcomes of interventions for ulcers in severe thalassemia.

resultsOf a total of 255 actively registered patients with HbE thalassemia in the 2 centers, 196 patient charts were evaluable. A leg ulcer with a documented date of onset was recorded in 45 (22%) of 196 evaluable patients, aged (mean ± SEM) 22.2 ± 1.4 years. Most had been irregularly transfused; steady-state hemoglobin was 6.4 ± 0.2 g/dL. Treatment achieving healing in 17 patients included transfusions, antibiotics, oral zinc, wound toileting, and skin grafting.

conclusionLeg ulcers may be more common in HbE beta thalassemia than in other forms of thalassemia. A systematic approach to treatment will be needed to document the prevalence and factors placing such patients at risk for leg ulcers. Controlled trials to evaluate the optimal treatment of this common complication are indicated.

Indexed as

beta-ThalassemiaHemoglobin ELeg UlcerThalassemiaHumansWound HealingHemoglobin EBeta-thalassemiaHemoglobin E beta thalassemiaThalassemiaUlcer

Identifiers

PMID34753145
PMCPMC9227683
OpenAlexW3213485705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.