ReviewAnnual review of medicine2022
Treatment of Delirium During Critical Illness.
Review in Annual review of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data.PloS one · 2023Pooled it
- The study on delirium side-effects after ultra-brief pulse electroconvulsive therapy.BMC psychiatry · 2025Trial
- Impact of Prior Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use on Delirium Incidence in ICU Patients: A Retrospective Study.Health science reports · 2026Article
- Article
- Zuranolone mitigates delirium-like bispectral EEG changes, behavioral deficits, and neuroinflammation across surgical and inflammatory mouse models and age groups.bioRxiv : the preprint server for biology · 2026Article
- Therapeutic Potentials of Anesthetics.Current neuropharmacology · 2026Article
- Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.BMC oral health · 2025Article
- Clinical Nursing Management of Adult Patients with Delirium in a Hospital Setting-A Systematic Review.Journal of clinical medicine · 2025Review
- Withdrawal-Induced Delirium in Opioid Dependence: A Systematic Review.Brain sciences · 2025Review
- Impact of Adjuvant Mannitol Administration on the Development of Delirium in Patients with Myocardial Infarction: Results of a Single-Center Pilot Study.Journal of clinical medicine · 2025Article
- Delirium as a mediating factor in the survival benefits of dexmedetomidine in acute brain injury management.Scientific reports · 2025Article
- Association between long-term (current) aspirin use and sepsis-related delirium in elderly patients: a retrospective cohort study.Aging clinical and experimental research · 2025Article
- Article
- Drug-Induced Cognitive Impairment.Drug safety · 2025Review
- Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study.Critical care (London, England) · 2025Observational
- To: Delirium and sleep quality in the intensive care unit: the role of melatonin.Critical care science · 2025Article
- Mobilization in Neurocritical Care: Challenges and Opportunities.Current neurology and neuroscience reports · 2024Review
- High level of systemic immune inflammation index elevates delirium risk among patients in intensive care unit.Scientific reports · 2024Article
- Effect of prophylactic perphenazine on delirium after extubation in severe acute pancreatitis.European journal of medical research · 2024Article
- Promoting Family Involvement in the Management of Delirium in Intensive Care: Scoping Review.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Delirium, an acute disturbance in mental status due to another medical condition, is common and morbid in the intensive care unit. Despite its clear association with multiple common risk factors and important outcomes, including mortality and long-term cognitive impairment, both the ultimate causes of and ideal treatments for delirium remain unclear. Studies suggest that neuroinflammation, hypoxia, alterations in energy metabolism, and imbalances in multiple neurotransmitter pathways contribute to delirium, but commonly used treatments (e.g., antipsychotic medications) target only one or a few of these potential mechanisms and are not supported by evidence of efficacy. At this time, the optimal treatment for delirium during critical illness remains avoidance of risk factors, though ongoing trials may expand on the promise shown by agents such as melatonin and dexmedetomidine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.