Evidence map›Paper›PMID 34752102›Full record

ArticleJournal of medicinal chemistry2021

Noninvasive NIR Imaging of Senescence

Jun Liu, Xiaowei Ma, Chao Cui, Zixin Chen, Ying Wang, Philip R Deenik, Lina Cui

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 61 citations in OpenAlex.

  1. Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Senolytic Prodrugs: A Promising Approach to Enhancing Senescence-Targeting Intervention.Chembiochem : a European journal of chemical biology · 2024
    Review
  6. Musculoskeletal imaging of senescence.Skeletal radiology · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Senolysis Enabled by Senescent Cell-Sensitive Bioorthogonal Tetrazine Ligation.Angewandte Chemie (International ed. in English) · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jun LiuDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Xiaowei MaDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Chao CuiDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Zixin ChenDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Ying WangDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Philip R DeenikDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Lina CuiDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-8149-5206
University of New Mexico · USUniversity of Florida Health · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Probing the role of heparanase via in situ labelingR35GM124963 · NIGMS · UNIVERSITY OF NEW MEXICO · PI CUI, LINA · 2017 to 2021
$1.9M
NCI NIH HHS P30 CA118100NIGMS NIH HHS R35 GM124963
6 · The paper itself

Abstract

Cellular senescence, a process that arrests the cell cycle, is a cellular response mechanism for various stresses and is implicated in aging and various age-related diseases. However, the understanding of senescence in living organisms is insufficient, largely due to the scarcity of sensitive tools for the detection of cellular senescence

Indexed as

Cellular SenescenceAnimalsbeta-GalactosidaseComputer SimulationFluorescent DyesHeterograftsMiceSpectroscopy, Near-Infraredbeta-GalactosidaseFluorescent Dyes

Identifiers

PMID34752102
PMCPMC10880455
OpenAlexW3212336947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.