ArticleEMBO reports2022
A binary effector module secreted by a type VI secretion system.
Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Functional divergence and regulatory network of the type VI secretion system inJournal of bacteriology · 2026Review
- The multifunctional type VI secretion system ofApplied and environmental microbiology · 2025Review
- Article
- A new class of type VI secretion system effectors can carry two toxic domains and are recognized through the WHIX motif for export.PLoS biology · 2025Article
- Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools.Nature microbiology · 2024Article
- The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence.PLoS biology · 2024Article
- Insights into virulence: structure classification of themSystems · 2023Article
- Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system.Communications biology · 2023Article
- The RIX domain defines a class of polymorphic T6SS effectors and secreted adaptors.Nature communications · 2023Article
- Killing in the name of: T6SS structure and effector diversity.Microbiology (Reading, England) · 2023Review
- The T6SS-Dependent Effector Re78 ofBiology · 2023Article
- Recruitment of heterologous substrates by bacterial secretion systems for transkingdom translocation.Frontiers in cellular and infection microbiology · 2023Review
- Multiple T6SSs, Mobile Auxiliary Modules, and Effectors Revealed in a Systematic Analysis of the Vibrio parahaemolyticus Pan-Genome.mSystems · 2022Article
- A DNase Type VI Secretion System Effector Requires Its MIX Domain for Secretion.Microbiology spectrum · 2022Article
- An antibacterial T6SS in Pantoea agglomerans pv. betae delivers a lysozyme-like effector to antagonize competitors.Environmental microbiology · 2022Article
- Complete genome sequence of a multiple-stress-tolerant bacterium3 Biotech · 2022Article
- Toxin-antitoxin systems in pathogenic3 Biotech · 2022Review
- A binary effector module secreted by a type VI secretion system.EMBO reports · 2022Article
- Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Gram-negative bacteria use type VI secretion systems (T6SSs) to deliver toxic effector proteins into neighboring cells. Cargo effectors are secreted by binding noncovalently to the T6SS apparatus. Occasionally, effector secretion is assisted by an adaptor protein, although the adaptor itself is not secreted. Here, we report a new T6SS secretion mechanism, in which an effector and a co-effector are secreted together. Specifically, we identify a novel periplasm-targeting effector that is secreted together with its co-effector, which contains a MIX (marker for type sIX effector) domain previously reported only in polymorphic toxins. The effector and co-effector directly interact, and they are dependent on each other for secretion. We term this new secretion mechanism "a binary effector module," and we show that it is widely distributed in marine bacteria.
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